Transforming growth factor-beta-induced cell growth inhibition in human breast cancer cells is mediated through insulin-like growth factor-binding protein-3 action.

The Journal of Biological Chemistry
Youngman OhR G Rosenfeld

Abstract

Most estrogen receptor-negative breast cancer cells, including Hs578T cells, express mRNAs encoding insulin-like growth factor-binding protein (IGFBP)-3, as well as transforming growth factor (TGF)-beta receptors. Our previous studies (Oh, Y., Muller, H. L., Lamson, G., and Rosenfeld, R. G. (1993) J. Biol. Chem. 268, 14964-14971; Oh, Y., Muller, H. L., Pham, H. M., and Rosenfeld, R. G. (1993) J. Biol. Chem. 268, 26045-26048) have demonstrated a significant inhibitory effect of exogenous IGFBP-3 on Hs578T cell growth and existence of IGFBP-3-specific receptors that may mediate those direct inhibitory effect of IGFBP-3. TGF-beta is also a potent growth inhibitor in human breast cancer cells in vitro and regulates IGFBP-3 production in different cell systems, suggesting that IGFBP-3 is a major anti-proliferative factor and a key element for TGF-beta-induced growth inhibition in human breast cancer cells. In support of this hypothesis, we have demonstrated using Hs578T cells that: 1) TGF-beta stimulates IGFBP-3 gene expression and production prior to its inhibition of cell growth, 2) treatment with an IGFBP-3 antisense oligodeoxynucleotide selectively inhibits TGF-beta-induced IGFBP-3 synthesis and cell growth inhibition, and 3) tr...Continue Reading

References

Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G LamsonR G Rosenfeld
Jan 1, 1991·American Journal of Clinical Oncology·H Rochefort
Jan 14, 1994·Biochemical and Biophysical Research Communications·S E Pratt, M N Pollak
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·K WosikowskiU Eppenberger

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Citations

May 8, 1998·The Journal of Experimental Zoology·D D Pravtcheva, T L Wise
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·S KansraE Friedman
Sep 21, 2002·Microscopy Research and Technique·Lynette J Schedlich, Lloyd D Graham
Nov 11, 2008·Journal of Mammary Gland Biology and Neoplasia·D J FlintG J Allan
Jun 1, 1996·The International Journal of Biochemistry & Cell Biology·K M KelleyR G Rosenfeld
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Steven A Rosenzweig
Apr 6, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Tomasz MilewiczJanusz Ryś
Jun 21, 2002·Biochemical and Biophysical Research Communications·C M PerksJ M P Holly
Oct 6, 1999·Molecular and Cellular Endocrinology·S GianniniC M Rotella
Sep 25, 2002·Cancer Detection and Prevention·Ryo IzutaniHarumasa Ohyanagi
Mar 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D KatsarosM Massobrio
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·M M Rechler, D R Clemmons
Mar 27, 1998·Breast Cancer Research and Treatment·Y Oh
Apr 2, 1999·Acta Paediatrica. Supplement·V HwaR G Rosenfeld
Feb 5, 2009·BMC Cancer·Katherine R SchillerLaura J Mauro
Oct 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert G Maki
May 30, 2009·Endocrine Reviews·Sherryline Jogie-BrahimYoungman Oh
Oct 2, 2013·Endocrine-related Cancer·Callum Livingstone
Jun 24, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michael A Johnson, Sue M Firth
May 4, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Mohammad Reza SafarinejadShiva Safarinejad

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