Transforming growth factor-beta induced protein, betaIG-H3, is present in degraded form and altered localization in lattice corneal dystrophy type I

Experimental Eye Research
L TakácsA Berta

Abstract

Lattice corneal dystrophy type I (LCDI) is an inherited autosomal dominant local amyloidosis, restricted to the corneal stroma. Comparison of electrophoretic profiles of normal and dystrophic corneas revealed a 42 kD protein, which was present only in dystrophic corneas. The N-terminal sequence of this protein showed identity to transforming growth factor-beta induced gene product (betaIG-H3). A polyclonal antiserum was raised in chicken against a synthetic peptide identical to the N-terminal portion of betaIG-H3. On immunoblots, the antiserum stained the 42 kD band, and also a 68 kD band corresponding to the reported molecular weight of the intact betaIG-H3. In normal corneas, only the 68 kD band was present. Immunohistologically, the antiserum stained corneal subepithelial regions, including subepithelial deposits, in dystrophic corneas. In normal corneas, the staining was observed only in the epithelium. These results may reflect the role of betaIG-H3 in extracellular matrix construction and/or amyloid formation.

References

Jun 1, 1976·Archives of Ophthalmology·J D LanierB Togni
Feb 1, 1992·American Journal of Medical Genetics·M HaltiaB Frangione
Mar 30, 1990·Biochemical and Biophysical Research Communications·M HaltiaB Frangione
May 1, 1983·Archives of Ophthalmology·M M RodriguesS Chock
Feb 1, 1984·American Journal of Ophthalmology·D M Meisler, M Fine
Dec 1, 1993·The British Journal of Ophthalmology·T KiveläM Haltia
Jan 1, 1994·Nature Genetics·E M StoneL M Streb
Mar 1, 1961·American Journal of Ophthalmology·S T JONES, L E ZIMMERMAN
May 1, 1960·The British Journal of Ophthalmology·A J DARK, D S THOMSON

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Citations

Nov 27, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·V M PampukhaL A Livshits
Nov 5, 2003·American Journal of Ophthalmology·John F WarrenTodd P Margolis
Oct 24, 2002·European Journal of Biochemistry·Clair-Florent Schmitt-BernardAngel Argilés
Jul 27, 2001·Progress in Retinal and Eye Research·S KinoshitaK Okubo
Jun 5, 2004·Journal français d'ophtalmologie·C-F Schmitt-BernardA Argilès

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