PMID: 9537837Apr 16, 1998Paper

Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes

Glia
M K Winkler, E N Beveniste

Abstract

Leukocyte transmigration across the blood-brain barrier (BBB) is a cardinal feature of central nervous system (CNS) inflammation. Astrocytes form an integral part, both structurally and functionally, of the BBB. Vascular cell adhesion molecule-1 (VCAM-1), a member of the immunoglobulin gene superfamily, is involved in extravasation into inflamed tissues and activation of T-lymphocytes. In this study, we investigated the role of TGF-beta, an immunosuppressive cytokine, in regulating cytokine-induced VCAM-1 expression in astrocytes. Human astroglioma cell lines and primary human fetal astrocytes were examined for VCAM-1 gene expression after treatment with proinflammatory cytokines (TNF-alpha, IL-1beta, IFN-gamma) in the absence or presence of TGF-beta. Astroglioma cell lines as well as primary human fetal astrocytes expressed low levels of VCAM-1 constitutively, and the proinflammatory cytokines induced marked increases in VCAM-1 expression, particularly TNF-alpha and IL-1beta. The inclusion of TGF-beta1 or TGF-beta2 with the proinflammatory cytokines inhibited VCAM-1 gene expression to varying degrees (33-93%) in all the astroglioma cell lines and primary fetal cells. These results indicate that TGF-beta is an important regulat...Continue Reading

References

Dec 1, 1992·The Journal of Experimental Medicine·A A HurwitzJ W Berman
Jul 1, 1992·Journal of Neuroimmunology·M C Morganti-KossmannS M Wahl
Nov 1, 1992·Human Pathology·H A HorstJ S Kovach
Aug 1, 1992·Journal of Cellular Physiology·J R BetheaE N Benveniste
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A P KuruvillaG J Thorbecke
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Jan 1, 1994·Annual Review of Medicine·M P BevilacquaO Cecconi
Apr 1, 1995·Annals of Neurology·B Cannella, C S Raine
Jul 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J R GambleM A Vadas
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Nov 1, 1994·The Journal of Experimental Medicine·S M Wahl
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·R J DieboldT Doetschman
Aug 1, 1996·Trends in Neurosciences·J E Merrill, E N Benveniste

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Citations

Sep 22, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Anjana Yadav, Ronald G Collman
Aug 3, 1999·Journal of Neuroimmunology·S J Lee, E N Benveniste
Oct 2, 2001·Neurochemistry International·E N BenvenisteG M O'Keefe
Jan 26, 1999·Cytokine & Growth Factor Reviews·E N Benveniste
Jan 28, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hui Qin XingShuji Izumo
Oct 6, 2012·Retrovirology·Herwig KoppensteinerMichael Schindler
Sep 20, 2015·Cellular Signalling·Marianna AgassandianLouis J Vuga
Feb 3, 2007·Neurobiology of Disease·Henrietta M NielsenSabina M Janciauskiene
Jun 27, 2006·European Journal of Clinical Investigation·N A C H Brabers, H S L M Nottet
Jan 15, 2013·The European Journal of Neuroscience·Aurore QuiriéAnne Prigent-Tessier
Oct 4, 2006·Diabetes Research and Clinical Practice·S YenerS Yesil
Nov 9, 2005·International Immunopharmacology·Yingying LeJi Ming Wang
Mar 31, 2015·Brain Research·Luokun Xie, Shao-Hua Yang
Jan 22, 2020·Glia·Jessica L WilliamsRobyn S Klein
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S K ParkJ D Lee
Jun 7, 2019·Cancer Biotherapy & Radiopharmaceuticals·Wei-Qun GuanQi-Ming Ouyang
Aug 26, 1998·European Journal of Immunology·V T NguyenE N Benveniste
Nov 7, 1998·Journal of Medicinal Chemistry·B AguileraA Fernández-Mayoralas

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