Abstract
The gonadal development of chicken embryo is regulated by hormones and growth factors. Transforming growth factor beta (TGF-beta) isoforms may play a critical role in the regulation of growth in chicken gonads. We have investigated the effect of the TGF-beta isoforms on the number of germ and somatic cells in the ovary of the chicken embryo. Ovaries were obtained from chicken embryos at 9 days of incubation. They were organ-cultured for 72 h in groups treated with TGF-beta1, TGF-beta2, soluble betaglycan, TGF-beta1 plus soluble betaglycan, or TGF-beta2 plus soluble betaglycan, and untreated (control). TGF-beta1 and TGF-beta2 diminished the somatic cell number in the ovary of the chicken embryo at this age by inhibiting the proliferation of the somatic cells without increasing apoptosis. On the other hand, TGF-beta1 and TGF-beta2 did not affect the number of germ cells in the cultured ovary. The capacity of TGF-beta1 and TGF-beta2 to diminish the number of somatic cells in the ovary was blocked with soluble betaglycan, a natural TGF-beta antagonist. However, changes in the location of germ cells within the ovary suggested that TGF-beta promoted the migration of the germ cells from the ovarian cortex to the medulla. Thus, TGF-bet...Continue Reading
References
Jan 25, 1992·Lancet·M ShahM W Ferguson
Nov 1, 1990·Endocrinology·B K Gangrade, J V May
Jul 1, 1988·Endocrinology·J DorringtonJ J Bendell
Aug 1, 1988·Molecular Endocrinology·S B JakowlewA B Roberts
Aug 1, 1987·Endocrinology·M K SkinnerH L Moses
Jun 1, 1995·General and Comparative Endocrinology·A S LawD G Armstrong
Aug 1, 1994·Current Opinion in Genetics & Development·N A Wall, B L Hogan
Feb 1, 1994·The Journal of Cell Biology·F López-CasillasJ Massagué
Jan 1, 1993·Growth Factors·A B Roberts, M B Sporn
Jun 17, 1998·Endocrine Reviews·P P HuX F Wang
Feb 13, 1999·Cell·C Wylie
Mar 9, 1999·Developmental Biology·A J RichardsJ L Resnick
Jul 25, 2000·Mechanisms of Development·P KondaiahI B Dawid
Jul 27, 2000·Molecular Reproduction and Development·T S Park, J Y Han
Dec 22, 2000·Genes & Development·C PetritschM Oft
Mar 21, 2001·The Biochemical Journal·M M Vilchis-LanderosF López-Casillas
Mar 9, 2002·General and Comparative Endocrinology·Masa-aki Hattori MaNoboru Fujihara
May 22, 2002·Biology of Reproduction·Patricia E SaragüetaJ Lino Barañao
Jun 13, 2003·Biology of Reproduction·Kyoko InoueTakashi Minegishi
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Aug 6, 2003·Development·Kathleen A MolyneauxRuth Lehmann
Mar 25, 2004·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Tsuyoshi FujiokaMasa-Aki Hattori
Jul 23, 2004·Biology of Reproduction·A L JohnsonD C Woods
Dec 31, 2004·Cell Research·Ye Guang Chen, An Ming Meng
Feb 12, 2005·Human Reproduction Update·J L Juengel, K P McNatty
Feb 24, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Carmen MéndezEnrique Pedernera
Jul 5, 2005·Developmental Biology·Susana M Chuva de Sousa LopesChristine L Mummery
Citations
Jan 29, 2011·Marine Biotechnology·Charlotte CorporeauArnaud Huvet
Sep 29, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dabin PanKejiang Cao
Feb 1, 2008·Growth Factors·Mai A SarrajKaye L Stenvers
Jul 7, 2012·Growth Factors·Rene EscalonaCarmen Méndez
Nov 26, 2008·Animal Reproduction Science·Okanlawon OnagbesanEddy Decuypere
Jul 1, 2008·Cytokine·K ErginK Seyrek
Aug 14, 2021·Development·Martin Andres EstermannCraig Allen Smith