Transforming growth factor beta is increased in plasma of patients with hematologic malignancies after transfusion of platelet concentrates

Transfusion
D KunzM Böck

Abstract

Transforming growth factor beta 1 (TGF-beta 1) acts as a potent inhibitor of bone marrow proliferation. High concentrations were found in human platelets, which release this cytokine during storage. TGF-beta 1 levels during a storage period of 5 days were compared in the plasma of platelet concentrates prepared by apheresis or by the buffy coat method. In addition, TGF-beta 1 plasma levels were monitored in patients with hematologic malignancies before and after transfusion. TGF-beta 1 levels in the supernatant of platelet concentrates were found to be 55 times higher than those in the plasma of healthy volunteer donors. During storage, an additional increase was observed. Accordingly, the transfusion of platelet concentrates resulted in a significant increase of plasma TGF-beta 1 levels in patients with hematologic malignancies (before transfusion: 2.2 +/- 0.5 ng/mL; after transfusion: 2.9 +/- 0.6 ng/mL), and these higher levels persisted for at least 4 hours. Because TGF-beta 1 reduces the clonogenic capacity of hematopoetic progenitor cells, a myelosuppressive effect of platelet transfusions is suggested.

Citations

Dec 20, 1999·Transfusion Medicine Reviews·L A Chambers, J H Herman
Mar 6, 2003·Vox Sanguinis·Walter H DzikFrancesco Puppo
Jan 15, 2015·Growth Factors·Ilenia PellicciottaMary Helen Barcellos-Hoff
Oct 13, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Maria TylmanAnders Bengtsson
Dec 27, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jerard Seghatchian
Feb 24, 2015·Frontiers in Immunology·Moritz StollaNeil Blumberg

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