PMID: 8601720Feb 1, 1996Paper

Transforming growth factor-beta receptor binding and function are decreased in psoriatic dermal endothelium

The Journal of Investigative Dermatology
J P CaiY H Chin

Abstract

T lymphocyte adhere to dermal microvascular endothelial cells (DMEC.) as the first step in their emigration from the blood vasculature into diseased skin. Earlier studies have shown that the adhesiveness of cultured DMEC. from normal skin for lymphocytes can be blocked by transforming growth factor-beta1 (TGF-beta1). In contrast, TGF-beta1 has no effect on the adhesive properties of DMEC from psoriatic plaques, and this response is attenuated by the addition of interleukin-4 (IL-4). In the present study, we show that both TGF-beta1 and TGF-beta2, and to a lesser extent TGF-beta3 isoforms block the ability of normal but not psoriatic DMEC to bind lymphocytes. Pretreatment with TGF-beta1 selectively inhibited the tumor necrosis factor-alpha(TNF-alpha)-stimulated expression of E-selecting on normal DMEC but had no psoriatic DMEC. Scatchard analysis revealed both low- and high-affinity receptors on normal DMEC. The baseline number of high-affinity TGF-beta receptors was significantly reduced on psoriatic DMEC, whereas IL-4 treatment of DMEC altered the binding affinity but not the number of receptors. The protein and mRNA transcripts of type I and type II TGF-beta receptor genes were detectable in psoriatic DMEC. A reduction in the...Continue Reading

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Citations

Jan 30, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·H ZaherD Kadry
Nov 4, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Iwona FlisiakBozena Chodynicka
Mar 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew R MaceyJohn J Ryan
Oct 31, 2006·The Journal of Investigative Dermatology. Symposium Proceedings·Brian J NickoloffMark W Lingen
May 1, 1997·Kidney International·P Pintavorn, B J Ballermann

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