Transforming growth factor beta receptor II (TGFBR2) promoter region polymorphism in Brazilian breast cancer patients: association with susceptibility, clinicopathological features, and interaction with TGFB1 haplotypes

Breast Cancer Research and Treatment
Glauco Akelinghton Freire VitielloMaria Angelica Ehara Watanabe

Abstract

Transforming growth factor beta (TGFβ) has paradoxical effects in breast cancer (BC), inhibiting initial tumors while promoting aggressive ones. A polymorphism on TGFBR2 promoter region (G-875A, rs3087465) increases TGFβ type II receptor expression and is protective against cancer. Previously, we have shown that TGFB1 variants have subtype-specific roles in BC. This work sought to investigate the association between TGFBR2 and susceptibility and clinicopathological features in BC subgroups. TGFBR2 G-875A was analyzed through PCR-RFLP in 388 BC patients and 405 neoplasia-free women. Case-control analyses as well as interaction with TGFB1 haplotypes previously associated with BC were tested through age-adjusted logistic regression. Correlations between G-875A and clinicopathological parameters were assessed through Kendall's Tau-b test. All statistical tests were two-tailed (α = 0.05). TGFBR2 G-875A was protective against BC in additive, genotypic, and dominant models. In subgroup-stratified analyses, these effects were greater in hormonal receptor-positive and luminal-A tumors, but were not significant in other subgroups. Logistic models including TGFB1 variants showed that in luminal-A tumors, G-875A retained its significance w...Continue Reading

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Citations

Aug 28, 2019·Breast Cancer Research and Treatment·Sora Yasri, Viroj Wiwanitkit
Sep 29, 2019·Breast Cancer Research and Treatment·Glauco Akelinghton Freire VitielloMaria Angelica Ehara Watanabe
Apr 15, 2020·Journal of Cancer Research and Clinical Oncology·Glauco Akelinghton Freire VitielloMaria Angelica Ehara Watanabe

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