Transforming growth factor beta regulates differentiation and proliferation of human neuroblastoma

Experimental Cell Research
S ScarpaG Colletta

Abstract

The effects of transforming growth factor-beta1 (TGFbeta) on two human neuroblastoma cell lines, LAN-5 and SK-N-AS, and one human glioblastoma cell line, GL15, were evaluated. Of the three cultures, only two, SK-N-AS and GL15, had a complete response to TGFbeta, with induction of the following effects: (i) inhibition of cell proliferation; (ii) up-regulation of the extracellular matrix glycoprotein fibronectin, together with down-regulation of the VLA5 integrin receptor; (iii) up-regulation of histotype-specific cytoskeletal intermediate filaments (neurofilaments for neuroblastoma and GFAP for glioblastoma); and (iv) increase in the glycoprotein CD44, only in SK-N-AS. In the third cell line, neuroblastoma LAN-5, the effects exerted by TGFbeta consisted only of (i) neurofilament increase and (ii) morphological differentiation. The TGFbeta receptor pattern was different in each culture: SK-N-AS expressed low rates of type I and type II receptors and high rates of type III receptor; LAN-5 expressed high rates of type I, low rates of type II, and no type III; GL15 expressed high rates of all three receptors. These data suggest that TGFbeta can induce a histotype-specific cell maturation and that the neuroblastoma expressing low typ...Continue Reading

Citations

Nov 13, 2013·The Journal of Clinical Investigation·Erik H KnelsonGerard C Blobe
Jun 18, 2014·The Journal of Clinical Investigation·Erik H KnelsonGerard C Blobe
Nov 26, 2015·Cancer Letters·Lucia BorrielloYves A DeClerck
Nov 15, 2006·Journal of Biomedical Science·Chih-Ping MaoT-C Wu
Feb 27, 2003·The Oncologist·Karin C M StraathofHelen E Heslop
Feb 9, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angela L GaviglioGerard C Blobe
Nov 22, 2018·Frontiers in Immunology·Rebecca M RichardsRobbie G Majzner
Apr 24, 2018·BioMed Research International·Thitinee VanichapolSuradej Hongeng
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H GeminderA Ben-Baruch
Feb 28, 2020·Cancers·Celina L SzantoStefan Nierkens
Apr 24, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rachel A BurgaCatherine M Bollard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.