PMID: 8444747Jan 1, 1993Paper

Transforming growth factor-beta: signal transduction via protein kinase C in cultured embryonic vascular smooth muscle cells

In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association
R W WrennT H Rosenquist

Abstract

Transforming growth factor-beta (TGF-beta), an ubiquitous regulatory peptide, has diverse effects on the differentiation and behavior of vascular smooth muscle cells (VSMC). However, the molecular mechanism through which TGF-alpha exerts its effects remains obscure. We investigated the phosphoinositide/protein kinase C [PKC] signaling pathway in the action of TGF-beta on cultured embryonic avian VSMC of differing lineage: a) thoracic aorta, derived from the neural crest; and b) abdominal aorta, derived from mesenchyme. The second messenger responsible for activation of PKC is sn-1,2-diacylglycerol [DAG]; TGF-beta increased the mass amounts of DAG in the membranes of neural crest-derived VSMC concurrent with translocation of PKC from the soluble to the membrane fraction, but TGF-beta had no effect on the DAG or PKC of mesenchyme-derived VSMC. TGF-beta potentiated the growth of platelet-derived growth factor (PDGF)-treated, neural crest-derived VSMC; but abolished PDGF-induced growth of mesenchymal cells. It is concluded that molecular and functional responses of VSMC to TGF-beta are heterogeneous and are functions of the embryonic lineage of the VSMC.

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Citations

Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V L SylviaB D Boyan
Sep 1, 1993·Cancer Metastasis Reviews·M J Newman
Jul 25, 2003·Journal of Molecular and Cellular Cardiology·Martin Ulrich Braun, Daria Mochly-Rosen
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·F LangS Broër
Oct 23, 2009·American Journal of Physiology. Cell Physiology·George M RisingerEric W Howard
Oct 1, 1993·In Vitro Cellular & Developmental Biology. Animal·P F GadsonT H Rosenquist
Nov 4, 2009·Nature Reviews. Cardiology·Ismail El-Hamamsy, Magdi H Yacoub
Feb 19, 1998·Circulation Research·M BergwerffA C Gittenberger-de Groot
May 22, 2003·American Journal of Physiology. Renal Physiology·Constance E RunyanAnne-Christine Poncelet
Aug 16, 2000·American Journal of Physiology. Cell Physiology·M YamamotoD R Cooper
Jan 31, 2021·Genes·Tyler J CreamerElena Gallo MacFarlane

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