PMID: 9159492Apr 25, 1997Paper

Transforming growth factor-beta1 induces apoptosis of rat microglia without relation to bcl-2 oncoprotein expression

Neuroscience Letters
B G XiaoH Link

Abstract

Transforming growth factor-beta (TGF-beta) plays a role as an immunosuppressive cytokine within the central nervous system (CNS). The CNS cells targeted by action of TGF-beta1 have not been defined. In this study, we tested the effect of TGF-beta1 on microglia, astrocytes and oligodendrocytes from newborn rats. TGF-beta1 selectively induced apoptosis of microglia, and not of astrocytes or oligodendrocytes. To study the apoptotic mechanism, bcl-2 oncoprotein expression in microglia, astrocytes and oligodendrocytes was measured. Bcl-2 was mainly expressed in microglia, indicating that microglial bcl-2 does not prevent TGF-beta1-mediated microglial apoptosis. The relative protein expression of bcl-2 in microglia was not related to frequency of microglial apoptosis. Thus, TGF-beta1-induced microglial apoptosis was regulated by a bcl-2-independent mechanism. Expression of cytokine (IL-1beta, IL-6, IL-12, IFN-gamma and TNF-alpha) mRNA on microglia was not influenced by treatment with TGF-beta1.

References

Dec 15, 1991·Journal of Immunological Methods·P Matzinger

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Citations

May 26, 1998·Journal of the Neurological Sciences·B G Xiao, H Link
Mar 14, 2001·Brain Research. Brain Research Reviews·P Rezaie, P L Lantos
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova
Sep 4, 2012·International Journal of Molecular Sciences·Arpád DobolyiGábor Lovas
Oct 2, 2013·Surgical Neurology International·Russell L Blaylock
Apr 17, 2014·BioMed Research International·Eric J GonzalezMargaret A Vizzard
Mar 19, 2014·The International Journal of Neuroscience·Alonso Martínez-Canabal
May 23, 2014·Brain Research·Takayuki NaganoMotohiko Takemura
Aug 31, 2001·Microscopy Research and Technique·P J Gebicke-Haerter
Oct 5, 2001·Nature Reviews. Neuroscience·S M Allan, N J Rothwell
Nov 21, 2013·Journal of Neurochemistry·Kendall MitchellAviva J Symes
Apr 25, 2003·Cell and Tissue Research·Kayvon SalimiChristian Humpel
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K M DrescherM Rodriguez

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