PMID: 11929499Apr 4, 2002Paper

Transforming growth factor-beta1 mediates coexpression of the integrin subunit alphaE and the chymase mouse mast cell protease-1 during the early differentiation of bone marrow-derived mucosal mast cell homologues

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Steven H WrightH R P Miller

Abstract

Mucosal mast cells (MMC) play a central role in gut hypersensitivities and inflammation. They are morphologically, biochemically and functionally distinct from their connective tissue counterparts. Massive hyperplasia of MMC occurs 7-10 days after intestinal infection with nematodes but it has never been possible to replicate this phenomenon in vitro. (1) To determine whether mouse bone marrow-derived mast cells (mBMMC) grown in the presence of transforming growth factor (TGF)-beta1 could develop over the same time frame (7-10 days) as MMC in parasitized mice. (2) To compare the early expression of surface receptors (integrins alphaE and beta7, c-kit and FcepsilonR) with that of the MMC-specific granule chymase mouse mast cell protease-1 (mMCP-1). Mouse bone marrow cells were cultured in the presence of IL-9, IL-3 and Stem Cell Factor (SCF) with or without TGF-beta1. mBMMC were quantified after toluidine blue or Leishmans' staining. Expression of MMC-specific mouse mast cell proteases was analysed by ELISA, immunohistochemistry and RT-PCR. Surface antigen expression was characterized by flow cytometry and confocal microscopy. TGF-beta1 promotes the development of abundant MMC-like mBMMC from bone marrow progenitor cells with ki...Continue Reading

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Citations

Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·Catherine DuvernelleNelly Frossard
May 15, 2008·Journal of Leukocyte Biology·Jun-ichi KashiwakuraToshiaki Kawakami
Jan 22, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J K BrownH R P Miller
Feb 23, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tatsuya TegoshiNaoki Arizono
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A D PembertonH R P Miller
Jan 15, 2005·Neurobiology of Disease·Bettina MesplèsPierre Gressens
Nov 3, 2005·Experimental Hematology·Mohit KashyapJohn J Ryan
Nov 15, 2006·Scandinavian Journal of Gastroenterology·Kirsi VaaliTimo Palosuo
Aug 25, 2016·The Journal of Allergy and Clinical Immunology·Asuka HonjoToshiaki Shimizu
Jul 27, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elaine Zayas Marcelino da SilvaConstance Oliver
Aug 18, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jeremy K BrownHugh R P Miller
Mar 16, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·F De JongeA B A Kroese
Jan 19, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Nada AbdellahRoeland Buckinx
Oct 23, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J W RychterA B A Kroese
Feb 2, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazumi KasakuraChiharu Nishiyama
Aug 25, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susumu YamazakiToshiaki Shimizu
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne RosbottomHugh R P Miller
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria EkoffGunnar Nilsson
Sep 19, 2020·The Journal of Experimental Medicine·Tahereh DerakhshanDaniel F Dwyer
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei ZhaoLawrence B Schwartz
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Eleanor Ling, Douglas S Robinson
Aug 26, 2006·Immunology and Allergy Clinics of North America·Yukihiko KitamuraAkihiko Ito
Nov 21, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nobuhiro NakanoKo Okumura

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