Transforming growth factor-beta1 regulates the expression of the high-affinity receptor for IgE on CD34 stem cell-derived CD1a dendritic cells in vitro

The Journal of Investigative Dermatology
Jean-Pierre AllamNatalija Novak

Abstract

It has been reported that monocytes, Langerhans cells (LC) and other dendritic cells (DC) express the high-affinity receptor for IgE (FcepsilonRI) in patients with atopic diseases. These cells may be instrumental in the control of the immune response and the allergic inflammation. In this context, transforming growth factor beta 1 (TGF-beta1) has been highlighted as a key cytokine involved in the mechanisms aimed to orchestrate tolerance and has been suggested as a candidate gene in atopic diseases. In this report, we investigate the putative role of TGF-beta1 in the regulation of FcepsilonRI on cord blood CD34+ stem cell-derived CD1a+ DC (CD34-derived CD1a+ DC). Kinetic experiments show that FcepsilonRI spontaneously appears on the surface of CD1a+ DC, but decreases when exogenous TGF-beta1 is added at high doses (10 ng per mL) or when endogenous TGF-beta1 is neutralized in the culture conditions. In contrast, low-dose TGF-beta1 (0.5 ng per mL) stabilizes surface FcepsilonRI expression on DC. Increasing TGF-beta1 concentrations leads to the generation of LC-like DC showing an augmentation in stimulatory capacity towards allogeneic T cells. In view of these data, a picture emerges that FcepsilonRI+ on DC is finely modified by t...Continue Reading

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Citations

Feb 16, 2005·International Archives of Allergy and Immunology·J-P AllamN Novak
Jun 15, 2011·Immunotherapy·Nerin Nadir Bahceciler, Nazan Cobanoglu
Jun 7, 2005·Expert Opinion on Biological Therapy·Johan VerhagenMübeccel Akdis
Nov 29, 2005·Clinical and Experimental Dermatology·J-P Allam, N Novak
Dec 2, 2005·International Reviews of Immunology·Johan VerhagenCezmi A Akdis
Feb 27, 2015·Cellular and Molecular Life Sciences : CMLS·Jeoung-Sook Shin, Alexandra M Greer
Feb 7, 2006·The Journal of Biological Chemistry·David M CauviMichael W Robertson
Oct 18, 2011·Current Opinion in Allergy and Clinical Immunology·Jean-Pierre Allam, Natalija Novak
Sep 12, 2009·Current Opinion in Allergy and Clinical Immunology·Jean-Pierre AllamNatalija Novak
Sep 19, 2014·Current Opinion in Allergy and Clinical Immunology·Jean-Pierre Allam, Natalija Novak
Oct 28, 2014·Expert Review of Vaccines·Nerin N BahcecilerNilufer Galip
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uzma HasanElizabeth E M Bates
Feb 20, 2008·Immunology and Allergy Clinics of North America·Jason JunMichael B Raizman

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