PMID: 11929498Apr 4, 2002Paper

Transforming growth factor-beta1 suppresses atopic dermatitis-like skin lesions in NC/Nga mice

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
K SumiyoshiH Ogawa

Abstract

Atopic dermatitis is a chronic, relapsing inflammatory disorder characterized by pruritic and eczematous skin lesions. Transforming growth factor (TGF)-beta1 has been implicated in the suppression of inflammatory responses. The purpose of this study is to determine whether TGF-beta1 suppresses skin lesions in a mouse model of atopic dermatitis. We used the NC/Nga strain of mice as an in vivo model of atopic dermatitis. The effects of exogenous TGF-beta1 on atopic dermatitis-like skin lesions in NC/Nga mice were evaluated clinically, histologically and immunologically. Subcutaneous injection of recombinant TGF-beta1 macroscopically suppressed eczematous skin lesions in NC/Nga mice associated with reduced serum immunoglobulin E (IgE) levels. Histological analysis showed that TGF-beta1 significantly inhibited the infiltration of inflammatory cells such as mast cells and eosinophils into the skin of NC/Nga mice. Spontaneous interferon (IFN)-gamma production from splenocytes of NC/Nga mice was down-regulated by the treatment with TGF-beta1 and neutralizing antibody against IFN-gamma inhibited skin lesions in NC/Nga mice. The inhibitory effect of TGF-beta1 on the skin lesions lasted at least 1 week after cessation of the treatment. T...Continue Reading

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Citations

Sep 19, 2003·The Journal of Allergy and Clinical Immunology·Houshang RafatpanahPeter D Arkwright
Mar 5, 2003·Journal of Dermatological Science·Koji SumiyoshiHideoki Ogawa
Mar 31, 2010·Immunology and Cell Biology·Sandrine DubracSusanne Ebner
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May 13, 2005·Photodermatology, Photoimmunology & Photomedicine·Hiroko Miyauchi-HashimotoTakeshi Horio
Feb 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T MatsubaraT Matsuda
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Oct 14, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T FukuyamaW Bäumer
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Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Eleanor Ling, Douglas S Robinson
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Myun Soo KimDaeho Cho

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