PMID: 9541223Apr 16, 1998Paper

Transforming growth factor-beta1 (TGF-beta1) in dentine matrix. Ligand activation and receptor expression

European Journal of Oral Sciences
A J SmithR C Hall

Abstract

Transforming Growth Factor-beta (TGF-beta) and other members of this family of growth factors have been implicated in tooth development and dental tissue repair. This study aimed to investigate regulatory factors for TGF-beta1 in rabbit incisor dentine matrix and the expression of receptors for TGF-beta in dental tissues better to understand the control of its biological activity. Approximately half of the TGF-beta1 in dentine matrix was present in active form. TGF-beta1 was found in association with latency associated peptide (LAP), betaglycan and decorin in an isolated dentine matrix preparation. Immunohistochemistry showed strong staining for TGF-beta type I and II receptors in odontoblasts with more variable and weaker staining of other pulpal cells. Association of TGF-beta1 with betaglycan, decorin and LAP may regulate the availability and biological activity of this growth factor and influence its presentation to the TGF-beta type I and II receptors on odontoblasts. During dental tissue repair, such control processes will be important in regulating the biological effects of TGF-beta1 on cells of the dentine-pulp complex.

Citations

Apr 21, 2001·The Journal of Clinical Pediatric Dentistry·H Ibricevic, Q al-Jame
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A J Smith, H Lesot
Dec 20, 2002·Connective Tissue Research·Marion LucchiniJean-Christophe Farges
Feb 14, 2008·Clinical Oral Investigations·A J SmithP R Cooper
Feb 13, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cristiane FuruseVera Cavalcanti de Araújo
Dec 12, 2012·International Journal of Oral Science·Xiao-Feng Huang, Yang Chai
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Apr 14, 2019·Journal of Tissue Engineering and Regenerative Medicine·Jie LiJinlin Song
Dec 25, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Peter E MurrayCharles F Cox
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Dec 20, 2002·Connective Tissue Research·A J SloanA J Smith
Feb 6, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Michel Goldberg, Anthony J. Smith
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