Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta

Journal of Neuroscience Research
Yuichi HashimotoMasaaki Matsuoka

Abstract

Amyloid beta (Abeta), the major component of the senile plaques of Alzheimer's disease, is implicated in neuronal cell death. We have found that Abeta42, a neurotoxic form of Abeta peptide, induces both neuronal and glial expression of TGFbeta2. We have further demonstrated that the addition into culture media of neutralizing antibody to TGFbeta2 or a large amount of the recombinant soluble amyloid precursor protein alpha, the extracellular domain of amyloid precursor protein (APP) generated by alpha secretase, suppresses death in primary cortical neurons (PCNs) induced by Abeta42 in vitro. Combined with the finding in our recent study indicating that TGFbeta2 is a neuronal cell death-inducing ligand for APP, it is suggested that TGFbeta2 is an autocrinal mediator for Abeta42-induced death in PCNs.

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Citations

May 9, 2012·TheScientificWorldJournal·Jose Miguel Rubio-Perez, Juana Maria Morillas-Ruiz
Apr 9, 2010·The International Journal of Neuroscience·Atsushi NoguchiMasaaki Matsuoka
Feb 27, 2010·Biochemical and Biophysical Research Communications·Nobuyuki TachiMasaaki Matsuoka
May 21, 2008·Nature Reviews. Neuroscience·Phillip G Popovich, Erin E Longbrake
Nov 1, 2018·Molecular Neurobiology·Luan Pereira DinizFlávia Carvalho Alcantara Gomes
Jun 5, 2015·Oncotarget·Alexei Kurakin, Dale E Bredesen
Jul 25, 2012·Annals of the New York Academy of Sciences·Heidemarie GastAdriano Fontana

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