Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Souhila AhdjoudjPierre J Marie

Abstract

Skeletal unloading induced by hindlimb suspension in rats reduces bone formation and induces osteopenia, but its effect on adipogenesis is unknown. We assessed the effects of unloading and transforming growth factor (TGF) beta2 on bone marrow stromal cell adipocyte differentiation in relation with osteoblast differentiation. Skeletal unloading rapidly (4-7 days) decreased osteoblast transcription factor Runx2, osteocalcin (OC), and type I collagen messenger RNA (mRNA) levels and reduced bone formation in the long bone metaphysis. Conversely, unloading increased expression of the adipocyte transcription factor peroxisome proliferator-activated receptor gamma2 (PPARgamma2) at 4 days and increased expression of the adipocyte differentiation genes lipoprotein lipase (LPL) and aP2 in the bone marrow stroma at 7 days. Consistently, unloading increased the number and volume of adipocytes in the bone marrow stroma. Continuous (0-7 days) and late (4-7 days) treatments with TGF-beta2 corrected the abnormal expression of Cbfa1/Runx2, OC, and type I collagen mRNAs and normalized bone formation in unloaded metaphyseal bone. Moreover, both TGF-beta2 treatments decreased PPARy2 and C/EBPalpha mRNA levels at 4 days and normalized aP2 and LPL e...Continue Reading

References

Oct 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C MarcelliG R Mundy
Nov 1, 1989·Molecular and Cellular Biology·J M GimbleC S Wang
Jun 1, 1989·Clinical Rheumatology·P Minaire
Jun 1, 1989·Endocrinology·M Noda, J J Camilliere
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A Ignotz, J Massagué
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jan 1, 1982·Metabolic Bone Disease & Related Research·T J Wronski, E R Morey
Mar 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R ZhangD J Simmons
May 15, 1994·Genes & Development·P TontonozB M Spiegelman
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·F T Lin, M D Lane
Feb 1, 1994·Endocrine Reviews·M CentrellaT L McCarthy
May 1, 1993·The American Journal of Physiology·M MachwateP J Marie
Jan 1, 1996·The Journal of Cell Biology·A Erlebacher, R Derynck
Apr 1, 1996·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·O KajkenovaD A Lipschitz
Jan 27, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D D DiascroA Schmidt
Mar 12, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D L ThompsonE E Moore
Mar 12, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K C HicokB L Riggs
Jul 23, 1998·Physiological Reviews·F M GregoireH S Sul
Apr 2, 1999·Science·M F PittengerD R Marshak
Jul 21, 1999·Journal of Cellular Biochemistry·B Lecka-CzernikR L Jilka
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F GoriB L Riggs
Dec 22, 1999·Current Opinion in Cell Biology·Z WuB M Spiegelman
May 3, 2000·The Journal of Cell Biology·L ChoyR Derynck

❮ Previous
Next ❯

Citations

Aug 13, 2013·Cellular and Molecular Life Sciences : CMLS·Agnes D Berendsen, Bjorn R Olsen
Dec 20, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Marie Hélène Lafage-ProustLaurence Vico
Jul 20, 2012·Annual Review of Nutrition·Sue A Shapses, Deeptha Sukumar
Sep 6, 2013·Stem Cell Research & Therapy·Julia C Chen, Christopher R Jacobs
Dec 3, 2010·The Journal of Biological Chemistry·Julie M QuachT John Martin
Feb 25, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine J MotylLaura R McCabe
May 12, 2010·Journal of Bone and Mineral Metabolism·Caroline HaboldDavid Brasse
Oct 21, 2005·The Keio Journal of Medicine·Ryota DeshimaruShiro Nozawa
Jul 5, 2007·Histochemistry and Cell Biology·Lindsay M Martin, Laura R McCabe
Mar 26, 2014·Journal of Cellular Physiology·Eun-Jin LeeEun-Ju Chang
Jul 30, 2016·Frontiers in Endocrinology·Gabriel M Pagnotti, Maya Styner
Oct 4, 2016·Frontiers in Endocrinology·Olfa GhaliChristophe Chauveau
Oct 7, 2016·Frontiers in Endocrinology·Michaela Tencerova, Moustapha Kassem
Dec 31, 2016·Journal of Cardiovascular Translational Research·Sonia EirasJosé R González-Juanatey
Apr 8, 2017·Nutrition Research·Sue A ShapsesYang Wang
Jan 18, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel L BelavyGuy Trudel
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Clifford J Rosen, Mary L Bouxsein
Sep 12, 2017·Annals of the New York Academy of Sciences·Danielle M FrechetteClinton T Rubin
Jan 18, 2003·Journal of Cellular Biochemistry·C Ontiveros, Laura R McCabe
May 15, 2003·Arthritis and Rheumatism·Andrea BarberoIvan Martin
Jul 18, 2003·Journal of Neuroscience Research·A E WillingP R Sanberg
Oct 31, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jordan M SpatzMary L Bouxsein
Feb 6, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pierre J Marie
Oct 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shinya TanakaToshitaka Nakamura
Sep 15, 2006·Journal of Cellular Physiology·Sergiu Botolin, Laura R McCabe
Dec 15, 2004·Journal of Cellular Biochemistry·Stefan JudexClinton T Rubin
Nov 3, 2007·Journal of Cellular Biochemistry·Laura R McCabe
Oct 22, 2008·Journal of Cellular Physiology·Katherine J Motyl, Laura R McCabe
Jul 6, 2018·European Journal of Endocrinology·Tareck Rharass, Stephanie Lucas
May 18, 2010·Medicine and Science in Sports and Exercise·Laurent BégotXavier Holy
Aug 4, 2010·Plastic and Reconstructive Surgery·Benjamin LeviMichael T Longaker
Apr 27, 2007·Journal of the American Society of Nephrology : JASN·Uta KunterJürgen Floege
Feb 16, 2006·Journal of Cellular Biochemistry·Jeffrey M GimbleMark E Nuttall
Jan 30, 2007·PPAR Research·P J Marie, K Kaabeche

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved