Transforming growth factor beta(2) lowers the incidence of incisional hernias

The Journal of Surgical Research
M G FranzM C Robson

Abstract

Approximately 200,000 incisional hernias are repaired annually in the United States. The high incidence (11-20%) and recurrence rate (24-54%) for incisional hernias have not changed appreciably in 75 years. Mechanical advances in suture material, incision orientation, and closure technique have failed to eliminate this common surgical complication. A biological approach to acute wound failure may offer a new strategy. A rodent incisional hernia model was used. Seventy rats underwent 5-cm midline celiotomies and were closed with fine, fast-absorbing sutures to induce intentional acute wound failure. Group 1 received no other treatment. The midline fascia in groups 2 and 3 was injected immediately prior to incision with 100 microl of vehicle alone or vehicle containing 1 microg of transforming growth factor beta(2) (TGF-beta(2)). Necropsy was performed on Postoperative Day 28 and the wounds were examined for herniation. Incisional hernias developed in 88% (35/40) and 79% (11/14) of untreated incisions and those treated with vehicle alone. No hernias formed in the TGF-beta(2)-treated incisions (0/16, P < 0.05). Standard histology and immunohistochemistry demonstrated enhanced macrophage, lymphocyte, and fibroblast chemotaxis and i...Continue Reading

References

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Citations

Jun 19, 2010·International Journal of Molecular Sciences·Pornanong AramwitTeerapol Srichana
Feb 13, 2008·The Surgical Clinics of North America·Michael G Franz
Jun 26, 2003·The Surgical Clinics of North America·Derek A Dubay, Michael G Franz
May 25, 2005·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M KorenkovM Nagelschmidt
Jul 27, 2005·Inflammatory Bowel Diseases·Robert M PennerRichard N Fedorak
Feb 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Martin C RobsonMichael G Franz
Aug 24, 2013·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J BurcharthJ Rosenberg
Jul 26, 2006·Surgical Endoscopy·J W A BurgerJ Jeekel
Feb 20, 2008·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A CingiA O Aktan
Mar 18, 2008·The British Journal of Surgery·U Klinge
Apr 20, 2010·Hernia : the Journal of Hernias and Abdominal Wall Surgery·W B GaertnerJ P Delaney
Apr 2, 2011·Langenbeck's Archives of Surgery·Karsten JungePetra Lynen Jansen
Jun 26, 2015·Advanced Healthcare Materials·Olivier GuillaumeAlexander Petter-Puchner
Apr 7, 2005·Acta Cirúrgica Brasileira·Renato Miranda de MeloAlcino Lázaro da Silva
May 13, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Frank H Lau, Bohdan Pomahac
Aug 5, 2004·Clinical Orthopaedics and Related Research·H BurmeisterR Ganz
Mar 15, 2003·Clinics in Plastic Surgery·Martin C Robson
Jun 26, 2003·The Surgical Clinics of North America·Ginard Henry, Warren L Garner

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