PMID: 1335097Jan 11, 1992Paper

Transforming growth factors and related peptides in gastrointestinal neoplasia

Journal of Cellular Biochemistry. Supplement
R J CoffeyW H Polk

Abstract

Transforming growth factor alpha and beta 1 (TGF alpha and TGF beta 1) are representative members of two distinct and expanding families of polypeptide growth factors. TGF alpha is an epithelial cell mitogen, whereas TGF beta 1 inhibits epithelial cell growth; the role of these factors in contributing to the transformed phenotype is uncertain. Steady state mRNA expression for these growth factors and their receptors in a panel of human colon cancers and adjacent normal mucosa is presented. Based in part on results from transgenic mice in which TGF alpha is selectively overproduced in the mammary gland, a possible role for TGF alpha as a tumor promoter in the process of transformation is discussed.

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C L ArteagaD L Page
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F CiardielloD S Salomon
Dec 1, 1991·The American Journal of Physiology·J A BarnardR J Coffey
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G D PlowmanM Shoyab
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M H KrausS A Aaronson
Mar 15, 1989·International Journal of Cancer. Journal International Du Cancer·L T MaldenA W Burgess
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E FinziS A Aaronson
Jan 1, 1988·Advances in Cancer Research·S H Yuspa, M C Poirier
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ShoyabG J Todaro
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H KurachiT Oka
Aug 1, 1984·The Journal of Clinical Investigation·F J Hendler, B W Ozanne
May 1, 1981·Critical Reviews in Toxicology·T S Argyris

❮ Previous
Next ❯

Citations

Apr 29, 1998·Diseases of the Colon and Rectum·K S ShimE B Park
Sep 27, 2005·The Journal of Pathology·Concetta TuccilloMarco Romano
Mar 26, 2003·The American Journal of Gastroenterology·Thomas J McGarrityMary K Howett
Mar 25, 2010·Cancer Prevention Research·Heather A PangburnPamela L Rice
Jul 1, 1995·Critical Reviews in Oncology/hematology·D S SalomonN Normanno
Jan 13, 1998·Biochimica Et Biophysica Acta·K S Kolibaba, B J Druker
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C TuccilloM Romano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.