PMID: 1335097Jan 11, 1992Paper

Transforming growth factors and related peptides in gastrointestinal neoplasia

Journal of Cellular Biochemistry. Supplement
R J CoffeyW H Polk


Transforming growth factor alpha and beta 1 (TGF alpha and TGF beta 1) are representative members of two distinct and expanding families of polypeptide growth factors. TGF alpha is an epithelial cell mitogen, whereas TGF beta 1 inhibits epithelial cell growth; the role of these factors in contributing to the transformed phenotype is uncertain. Steady state mRNA expression for these growth factors and their receptors in a panel of human colon cancers and adjacent normal mucosa is presented. Based in part on results from transgenic mice in which TGF alpha is selectively overproduced in the mammary gland, a possible role for TGF alpha as a tumor promoter in the process of transformation is discussed.


Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C L ArteagaD L Page
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