Transfusion-associated graft-versus-host disease

European Journal of Internal Medicine
Ozgur Akin OtoYesim Tasova

Abstract

Transfusion-associated graft-versus-host disease (TA-GVHD) is a relatively rare and interesting entity. Despite a range of pathophysiological and therapeutic approaches, it has a high mortality. It is possible to prevent the disease by prophylaxis only. It is possible to miss the entity in routine clinical practice and reach a different diagnosis due to its non-specific signs and symptoms. Four patients with signs and symptoms suggestive of TA-GVHD were evaluated and the literature reviewed. The transfusion history was of great importance, as was the exclusion of other conditions that may present with similar signs and symptoms (fever, skin rash, diarrhea, pancytopenia, icterus and renal failure). Confirmation of TA-GVHD was by skin biopsy. TA-GVHD must be considered as a differential diagnosis in patients who present with fever, pancytopenia, diarrhea, skin rash and icterus, and the transfusion history must be questioned. Mortality is very high despite various therapeutic approaches. This makes prophylaxis essential. TA-GVHD can be prevented by irradiation of blood products and by avoiding the use of blood transfusions from family donors.

References

Mar 7, 1991·The New England Journal of Medicine·J L Ferrara, H J Deeg
Aug 1, 1984·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Y AokiY Sakakibara
Jul 1, 1995·Transfusion·M A PopovskyK C Anderson
Apr 1, 1994·British Journal of Haematology·M YasukawaS Fujita
Jun 1, 1994·Journal of Clinical Pathology·A L AppletonA J Malcolm
Jun 1, 1996·Pediatric Clinics of North America·C S Manno
Jan 1, 1996·Transfusion Medicine Reviews·H Ohto, K C Anderson
Oct 8, 1999·Revista da Associação Médica Brasileira·E P Landi, J S de Oliveira
Apr 26, 2002·British Journal of Haematology·Marlis L Schroeder
Jun 10, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Chris ParshuramSam D Shemie
Nov 5, 2003·Bone Marrow Transplantation·A van Royen-KerkhofG T Rijkers
Jun 30, 2005·Indian Journal of Pediatrics·Inderpreet Sohi, Sunitha Jacob

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Citations

Feb 1, 1989·Journal of the American Academy of Dermatology·P E LeBoit
Jun 5, 2015·Revista brasileira de hematologia e hemoterapia·Ricardo Aparecido OlivoHelio Moraes-Souza

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