Transfusion of 7-day-old amotosalen photochemically treated buffy-coat platelets to patients with thrombocytopenia: a pilot study

Transfusion
Anne C SimonsenJocelyne Flament

Abstract

Photochemical treatment (PCT) of platelets (PLTs) with amotosalen and ultraviolet A light to inactivate bacteria may facilitate extension of storage from 5 to 7 days. A randomized, double-blinded, crossover, noninferiority, single-site pilot study utilizing pooled buffy-coat PLTs was conducted. The primary endpoint was the 1-hour corrected count increment (CCI) after one transfusion each of 7-day-old PCT and reference (R) PLT components. Secondary endpoints included 1-hour count increment, time to next transfusion, hemostasis, transfusion reactions, and serious adverse events. Twenty patients with thrombocytopenia were randomly assigned: 9 to the PCT-R sequence and 11 to the R-PCT sequence. A significant treatment-by-period interaction was observed. Therefore, the first period only was also analyzed for the primary endpoint. Including both treatment periods, mean 1-hour CCI was 6587 +/- 4531 for PCT versus 8935 +/- 5478 for R-PLTs. For the first period only, mean 1-hour CCI was 8739 +/- 3785 for PCT versus 7433 +/- 5408 for R-PLTs. The upper bound of the one-sided 95 percent confidence interval of 2400 for the mean difference was higher than the specified noninferiority margin of 2200 for both analyses. Overall median time to n...Continue Reading

References

Jul 1, 1986·Transfusion·J M HealT Mayer
Jul 26, 2003·Transfusion Medicine·R Cardigan, L M Williamson
Dec 23, 2003·Transfusion Medicine Reviews·Morris A BlajchmanFederico Baeza
Apr 12, 2005·Transfusion·P A W te BoekhorstD J van Rhenen

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Citations

Nov 16, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Tor HervigTorunn Oveland Apelseth
Aug 25, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nahreen Tynngård
Feb 26, 2008·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nahreen TynngårdMona Hansson
Jun 22, 2007·Transfusion·Thomas ThieleAndreas Greinacher
May 29, 2010·British Journal of Haematology·Jean-Louis H KerkhoffsUNKNOWN Dutch - Belgian HOVON cooperative group
Jan 12, 2013·Transfusion·Lise J EstcourtUNKNOWN Biomedical Excellence for Safer Transfusion Collaborative
Nov 9, 2012·Vox Sanguinis·C V Prowse
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Lise J EstcourtMichael F Murphy

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