Transfusion of phosphoenolpyruvate-treated blood increases oxygen consumption in acute hemorrhage

American Journal of Surgery
R L CornumW C Bandy

Abstract

Incubating blood with phosphoenolpyruvate decreases hemoglobin oxygen affinity (HOA). This study compared transfusion with phosphoenolpyruvate-treated blood and conventionally stored blood on oxygen consumption in acutely anemic dogs. Dogs underwent isovolemic hemodilution (hematocrit = 10%). After 1 hour they were transfused to a hematocrit of 18% with control or phosphoenolpyruvate treated blood. Cardiac output, co-oxymetry, and hemoglobin P50 measurements allowed calculation of oxygen consumption during anemia, and posttransfusion. Hemodilution doubled cardiac output. Transfusion with phosphoenolpyruvate-treated blood allowed greater O2 consumption than control (8.31+/-2.1 and 3.73+/-0.11 cc/kg/mm). There were no differences in arterial or venous PO2 or pH; there were marked differences in HOA, measured by posttransfusion P50 (21+/-3 versus 47+/-4), and mixed venous O2 saturation. Decreased HOA results in increased O2 consumption in dogs subjected to anemic hypoxia. Phosphoenolpyruvate-treated blood provides increased oxygen consumption at a similar hematocrit when compared with untreated banked blood.

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Citations

Jan 13, 2001·Vox Sanguinis·N Hamasaki, M Yamamoto
Jul 4, 2017·Drug Testing and Analysis·Maimonah SulaimanK B Chan
Mar 4, 2000·Anaesthesia and Intensive Care·C Anstey
Jun 25, 2019·Frontiers in Physiology·Jonathan C Jun, Erik R Swenson

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