Transfusion of platelets containing ABO-incompatible plasma: a survey of 3156 North American laboratories.

Archives of Pathology & Laboratory Medicine
Mark K FungIra A Shulman

Abstract

Hemolytic transfusion reactions due to platelet transfusions containing ABO-incompatible plasma (ie, group O platelets into a non-group O patient) have been reported in the literature. However, limited data describe the extent to which transfusion services manage such platelet transfusions or the methods used to limit the risk of such reactions. To determine transfusion services' current practices regarding the use of platelets containing ABO-incompatible plasma. In a College of American Pathologists' Transfusion Medicine Proficiency Testing Survey, supplemental questions asked participants whether a policy existed for the use of platelets containing ABO-incompatible plasma and, if a policy existed, what elements were part of the policy. Of 3156 laboratories that transfused platelets, 3152 responded to the question of whether they had a policy. Of these respondents, 83% (n = 2623) had a policy. One or more elements were reported for transfusions in adults: only ABO-compatible plasma products (n = 1363); only ABO-compatible plasma and platelet products (n = 679); notification of medical director (n = 646); notification of ordering physician (n = 637); volume limit of ABO-incompatible plasma allowed (n = 255); volume-reduction of...Continue Reading

References

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Citations

Jun 24, 2020·Hematology, Transfusion and Cell Therapy·Gayathiri KcMaya Padmanaban
Apr 9, 2021·Transfusion·Maryam Asif, Bernard Khor
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Tamara R BelinAndrew P Cap
Dec 5, 2020·Hematology·Nancy M Dunbar
Jul 9, 2008·Archives of Pathology & Laboratory Medicine·J P AuBuchonUNKNOWN Transfusion Medicine Resource Committee of the College of American Pathologists
May 1, 2020·Journal of Thrombosis and Haemostasis : JTH·Melissa M Lee-SundlovKarin M Hoffmeister
Dec 29, 2012·The Journal of Trauma and Acute Care Surgery·Martin D ZielinskiJames R Stubbs

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