Transfusion reactions and cognitive aids

Current Opinion in Anaesthesiology
Anna Clebone

Abstract

Although the overall safety of blood transfusion is high, adverse events do still occur. Much research on transfusion reactions was done in nonperioperative patients. Fortunately, important contributions to the perioperative literature have been made in the last several years, specifically in the areas of transfusion-associated circulatory overload and transfusion-related acute lung injury (TRALI). An unfavorable reaction occurs in as many as 1% of transfusions overall, although the risk of death with each unit given is between 0.002 and 0.0005%. Specific, modifiable factors exist, however, of which the anesthesiologist should be aware. A 2017 article by Clifford et al. is the first to examine risk factors and outcomes for transfusion-associated circulatory overload in a high-risk noncardiac surgery population undergoing anesthesia and surgery. In recent years, limiting plasma donors to males only resulted in an approximately 50% decrease in TRALI. The current article explores new research on the topics of transfusion-associated circulatory overload and transfusion-related lung injury.

References

Nov 26, 2011·Blood·Pearl ToyUNKNOWN TRALI Study Group
Apr 30, 2014·Critical Care Medicine·Mark R LooneyUNKNOWN Transfusion-Related Acute Lung Injury Study Group
Apr 17, 2016·Lancet·Meghan DelaneyUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Dec 27, 2016·Transfusion·Pearl ToyMark R Looney
Aug 2, 2017·Anesthesia and Analgesia·Barbara K BurianKeith J Ruskin
Nov 15, 2017·Anesthesiology·Charles Boucek
Jan 1, 2018·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Anupam VermaZafar Neyaz

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