Transfusion-related acute lung injury (TRALI): clinical presentation, treatment, and prognosis

Critical Care Medicine
S Breanndan Moore

Abstract

The term transfusion-related acute lung injury (TRALI) was coined in 1983 to describe a constellation of clinical and laboratory features seen within 6 hrs of the transfusion of plasma-containing blood products. These products contain antibodies directed to human leukocyte antigens (and subsequently described to nonhuman leukocyte antigens) found on white blood cells. In the intervening 2 decades, other cases not associated with antibodies have been reported as TRALI and an association with passive infusion of lipids accumulated in stored cellular blood products has been made in those cases. This has led to confusion as to what should be considered to constitute TRALI. Therefore, the true incidence of this pulmonary reaction to blood products is currently conjectural at best. Recent consensus development conferences have been held to develop and standardize definitions of TRALI so that epidemiologic and research aspects of this condition can be explored in a scientific manner. These conferences have set out criteria by which TRALI is distinguished from other causes of acute lung injury. This review outlines the widely accepted clinical (mainly pulmonary) features of TRALI, the treatment options, and the excellent long-term prog...Continue Reading

Associated Clinical Trials

References

Jul 1, 1983·The American Review of Respiratory Disease·M A PopovskyS B Moore
May 8, 1999·British Journal of Haematology·P M Kopko, P V Holland
May 25, 2004·Anesthesia and Analgesia·Brian S Donahue
Jul 14, 2004·Chest·Mark R LooneyMichael A Matthay
Nov 25, 2004·Anesthesia and Analgesia·Pearl Toy, Ognjen Gajic
Dec 2, 2004·Blood·Christopher C SillimanLynn K Boshkov
Apr 9, 2005·Critical Care Medicine·Pearl ToyUNKNOWN National Heart, Lung and Blood Institute Working Group on TRALI
Apr 15, 2005·Transfusion Medicine Reviews·Mindy GoldmanUNKNOWN TRALI Consensus Panel
Jun 11, 2005·Mayo Clinic Proceedings·Ognjen Gajic, S Breanndan Moore

❮ Previous
Next ❯

Citations

Apr 6, 2013·Der Anaesthesist·S TankR Kiefmann
May 7, 2013·Lancet·Alexander P J Vlaar, Nicole P Juffermans
Oct 19, 2007·Annals of Surgical Oncology·Randal S WeberRobert C G Martin
Jan 1, 2014·Journal of the American Veterinary Medical Association·Elizabeth J Thomovsky, Jonathan Bach
May 13, 2014·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M BernasinskiJ-M Malinovsky
Apr 4, 2014·Journal of Cardiothoracic Surgery·Julien TeodoriGianni Davide Angelini
Dec 30, 2011·Indian Journal of Pediatrics·Shuchita GuptaRamesh Agarwal
Dec 24, 2013·The Journal of Emergency Medicine·Sam S TorbatiDaniel Niku
Aug 21, 2013·Clinical Imaging·Carolina CarcanoJacobo Kirsch
Jun 9, 2012·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·U J Sachs
Nov 27, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Michael G Wong, James A Helliwell
Feb 17, 2010·Medicina intensiva·J M AñónM J Bruscas
Oct 9, 2007·Obstetrics and Gynecology Clinics of North America·Andrea J Fuller, Brenda Bucklin
Oct 1, 2008·Pharmacotherapy·Kwame Asare
Oct 12, 2011·Transfusion·Rutger A MiddelburgJohanna G van der Bom
May 22, 2010·Journal of Veterinary Emergency and Critical Care·Jennifer E Prittie
Apr 30, 2015·British Journal of Haematology·Anna L PetersAlexander P J Vlaar
Dec 17, 2014·Transfusion·Rutger A Middelburg, Johanna G van der Bom
Apr 7, 2015·Korean journal of anesthesiology·Jeongmin Kim, Sungwon Na
Apr 21, 2009·Revista brasileira de anestesiologia·Beatriz Garcia Sluminsky, Ranger Cavalcante da Silva
Apr 5, 2017·Acta Anaesthesiologica Scandinavica·E VibedeA-M Hvas
Mar 29, 2008·Journal of Intensive Care Medicine·Randeep S JawaMahmoud N Kulaylat
Dec 12, 2017·International Anesthesiology Clinics·Gianni R Lorello, Asim Alam
Feb 6, 2010·European Journal of Gastroenterology & Hepatology·Jagdish S NachnaniLaura M Alba
Feb 10, 2010·Clinical Obstetrics and Gynecology·Andrea J Fuller, Brenda A Bucklin
Dec 20, 2007·Dimensions of Critical Care Nursing : DCCN·Carol A Dennison
Aug 28, 2015·The Open Respiratory Medicine Journal·P ÁlvarezR L Castillo
Jun 27, 2019·Transfusion·Dorien De ClippelVeerle Compernolle
Feb 22, 2007·Anesthesia and Analgesia·Jonathan H WatersMarina V Kameneva
Nov 5, 2013·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Michael T McEvoy, Aryeh Shander

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.