Transfusion-related sepsis after prolonged platelet storage

The American Journal of Medicine
K C AndersonB Sullivan

Abstract

The antecubital fossa venipuncture site in frequent blood donors can become scarred or "dimpled" and colonized with surface and deep bacteria that are not sterilized by standard iodophor preparation techniques. These microorganisms can be introduced into blood or platelets at the time of donation. Recent advances that permit the prolonged storage of platelets at room temperature before transfusion allow proliferation of these contaminating bacteria, particularly gram-positive microorganisms. Documented are three episodes of platelet contamination with gram-positive organisms and four cases of sepsis in recipients of these platelets, which were obtained through the "dimpled" site of a single donor and stored for at least 80 hours at 22 degrees C before transfusion. In contrast, platelets harvested from this donor's "dimpled" site and stored for not more than 50 hours were transfused to 25 patients without complication. Therefore, the extended storage of platelets at 22 degrees C prior to transfusion demands strict awareness of any possible sources of extrinsic contamination, since gram-positive bacteria can proliferate under these conditions and result in infectious complications in recipients.

References

May 1, 1985·Transfusion·I O Szymanski
Jun 1, 1973·Journal of Clinical Pathology·M Cunningham, J D Cash
Nov 1, 1970·Transfusion·A J Katz, R C Tilton
Aug 19, 1971·The New England Journal of Medicine·D H BuchholzM R Mardiney
Feb 1, 1971·The Journal of Clinical Investigation·S Murphy, F H Gardner
Sep 2, 1971·The New England Journal of Medicine·R I Handin, C R Valeri
Mar 1, 1984·Transfusion·G RockP Tittley
Jan 1, 1983·Archives of Internal Medicine·D J WinstonW J Martin
Sep 1, 1982·Transfusion·M A Stenhouse, L V Milner
Mar 1, 1974·Transfusion·B A MyhreM L White
Dec 1, 1953·Annals of Internal Medicine·A R STEVENSC A FINCH
Nov 8, 1958·Lancet·T GIBSON, W NORRIS
Jul 1, 1959·Vox Sanguinis·J D JAMES
Nov 15, 1951·The New England Journal of Medicine·C W BORDEN, W H HALL
Jun 1, 1952·The Journal of Laboratory and Clinical Medicine·A I BRAUDEO T MALLERY

❮ Previous
Next ❯

Citations

Jun 3, 2000·Gastroenterology Clinics of North America·U Beejay, M M Wolfe
May 7, 1998·Transfusion Medicine·C P McDonaldJ A Barbara
Jul 14, 2001·Vox Sanguinis·C P McDonaldJ A Barbara
Oct 18, 2001·Current Opinion in Hematology·F C Reading, M E Brecher
Jan 1, 1994·Vox Sanguinis·M A BlajchmanH L Richardson
Jan 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J GongI Gustafsson
Oct 22, 2009·Veterinary Clinical Pathology·Rebecca J KesslerUrs Giger
Jan 18, 2005·Clinical Microbiology Reviews·Mark E Brecher, Shauna N Hay
Jun 1, 1999·Leukemia & Lymphoma·I J Webb, K C Anderson
Jan 1, 1991·Transfusion Medicine Reviews·M Goldman, M A Blajchman
Sep 12, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jaisy Mathai
Oct 14, 2008·Transfusion Medicine Reviews·Jonathan N ThonDana V Devine
Jun 21, 2001·Blood Reviews·P L Perrotta, E L Snyder
Jun 3, 2000·Gastroenterology Clinics of North America·Y KupferS Tessler
Jan 1, 1995·Immunological Investigations·W Dzik
Jan 1, 1987·Journal of Clinical Apheresis·T R KiralyD F Norton
Mar 1, 1997·Transfusion·M GoldmanG Delage
Aug 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hani Nasser Abdelhamid, Hui-Fen Wu
Nov 25, 1998·Journal of Clinical Apheresis·J A GagnonS Glück
Jan 1, 1995·Immunological Investigations·M A Blajchman
Jul 1, 1994·Clinical Microbiology Reviews·S J WagnerR Y Dodd

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Related Papers

The British Journal of Ophthalmology
P J AddsS Hartley
JAMA : the Journal of the American Medical Association
J F MorrowA K Fuller
© 2021 Meta ULC. All rights reserved