PMID: 8597838May 1, 1995Paper

Transfusion-transmitted cytomegalovirus: the part-time pathogen

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
K C Gunter

Abstract

Viral infection is a well-known risk of blood product transfusion and much work has been devoted to the detection of such well-known pathogens as human immunodeficiency virus and hepatitis viruses in blood donors. Cytomegalovirus (CMV) is found in a much larger percentage of donor units than these other viruses but will cause disease in only a minority of recipients. Many pediatric patients (especially premature infants) are at risk for transfusion-transmitted CMV. This review describes work delineating the populations of patients most at risk for transfusion-transmitted CMV, describes methods for detecting CMV in blood donors, evaluates current methods for leuko-depletion of blood products, and provides recommendations for patients most likely to benefit from blood products with low risk of CMV transmission.

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Citations

May 1, 2001·Journal of Paediatrics and Child Health·D E Trincado, W D Rawlinson
Jun 1, 2018·Japanese Journal of Infectious Diseases·Konstantinos FragkiadakisDiamantis P Kofteridis

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