Transfusion-transmitted virus prevalence in Turkish patients with thalassemia

Pediatric Hematology and Oncology
Emel OzyürekFatma Gümrük

Abstract

In hematology patients on chronic transfusion regimes, liver diseases are frequent, and mostly related to the agents transmitted by blood products and concominant iron deposition in liver. Besides hepatitis B (HBV) and C (HCV) viruses, new viral agents like hepatitis G virus (HGV) and TorqueTeno virus (TTV) are identified in these patients, although their association with any pathology or disease is not yet proved. In the present work, the authors studied the clinical importance of TTV in Turkish multitransfused patients with thalassemia. Forty-six healthy and 57 thalassemic patients were enrolled in the study. TTV was detected in serum samples by 3'-UTR nested PCR. Transaminase and ferritin levels, hepatitis B and C virus markers and number of transfusions were interpreted for possible association with TTV infection. As a result, TTV was detected in 63% of the thalassemia and 54% of the control patients. Prevalence of TTV infection, clinical features, laboratory data, and annual transfusion numbers of TTV-positive and -negative patients were not observed to be statistically significant. In conclusion, in Turkish patients with thalassemia, TTV infection cannot be considered as a risk factor for liver disease.

References

Feb 12, 1998·Biochemical and Biophysical Research Communications·T NishizawaM Mayumi
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CharltonR Wiesner
Mar 23, 1999·British Journal of Haematology·S TakayamaS Sugii
Apr 26, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·R RubinsteinE J Van Rensburg
Jun 22, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·P BiaginiX de Lamballerie
Sep 12, 2001·Hepatology Research : the Official Journal of the Japan Society of Hepatology·A SiodaY Arakawa

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Citations

Jun 23, 2009·Transfusion·Seyed-Moayed AlavianKamran Bagheri Lankarani
Nov 14, 2007·Clinical & Experimental Ophthalmology·Sinan EmreRiza Durmaz
Jul 13, 2011·The Korean Journal of Hematology·Samin AlaviMasoumeh Navidinia
Oct 31, 2009·World Journal of Hepatology·Nabil Mohie Abdel-Hamid
Nov 7, 2012·Journal of Pediatric Hematology/oncology·Duran Canatan
Aug 11, 2020·Advanced Biomedical Research·Poupak MortazkarHossein Keyvani

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