Transfusion volume in infants with very low birth weight: a randomized trial of 10 versus 20 ml/kg

Journal of Pediatric Hematology/oncology
David A PaulJ L Stefano

Abstract

Although preterm infants often require transfusions of red blood cells for anemia of prematurity, the optimal volume of blood to be transfused has not been established. Infants with birth weights between 500 and 1,500 g were randomly assigned to receive 10 or 20 mL/kg red blood cells. Infants with transfusions of 20 mL/kg had a greater hemoglobin (14.2 +/- 1.9 vs. 12.0 +/- 1.9 g/dL, P = 0. 003) and hematocrit (41.2 +/- 5.9 vs. 32.3 +/- 7.1%, P = 0.001) levels after transfusion compared with those who received transfusions of 10 mL/kg. There were no measured differences in pulmonary function in either group after transfusion. Transfusion with 20 mL/kg red blood cells produces a significantly greater increase in hemoglobin and hematocrit levels than does a transfusion with 10 mL/kg, without any detrimental effects on pulmonary function.

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Citations

Jun 10, 2008·Indian Journal of Pediatrics·Richa JainAshok K Deorari
Feb 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·N A Murray, I A G Roberts
Jul 26, 2011·The Journal of Pediatrics·Kiran Kumar Balegar V, Martin Kluckow
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Nov 20, 2016·European Journal of Pediatrics·Rakesh Kumar PilaniaPraveen Kumar
Apr 6, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rajbir Kaur CheemaDeepak Chawla
Jul 10, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Eui Kyung ChoiByung Min Choi

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