Transgelin-2 in immunity: Its implication in cell therapy

Journal of Leukocyte Biology
Suin JoChang-Duk Jun

Abstract

Transgelin-2 is a small 22-kDa actin-binding protein implicated in actin dynamics, which stabilizes actin structures and participates in actin-associated signaling pathways. Much curiosity regarding transgelin-2 has centered around its dysregulation in tumor development and associated diseases. However, recent studies have shed new light on the functions of transgelin-2, the only transgelin family member present in leukocytes, in the context of various immune responses. In this review, we outlined the biochemical properties of transgelin-2 and its physiological functions in T cells, B cells, and macrophages. Transgelin-2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. Transgelin-2 in B cells also participates in the stabilization of T cell-B cell conjugates. While transgelin-2 is expressed at trace levels in macrophages, its expression is highly upregulated upon lipopolysaccharide stimulation and plays an essential role in macrophage phagocytosis. Since transgelin-2 increases T cell adhesion to target cells via boosting the "inside-out" costimulatory activation of leukocyte function-associated antigen 1, transgelin-2 could be a suitable candidate to potentiate the antitumor respon...Continue Reading

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Citations

May 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francisco J OrtegaJosé M Fernández-Real
Apr 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Lian LiuJonathan M Peake
Oct 30, 2020·Frontiers in Cell and Developmental Biology·Jingwen LiuYan Wang
Jul 2, 2019·Trends in Biochemical Sciences·Lei-Miao YinYong-Qing Yang
Mar 19, 2021·Journal of Hematology & Oncology·Hye-Ran KimChang-Duk Jun
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Ji WuJia-Yi Tang
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Hye-Ran KimChang-Duk Jun

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