Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance

Endocrine Journal
Mototsugu NagaoShinichi Oikawa

Abstract

We recently established 2 mouse lines with different susceptibilities (prone and resistant) to high-fat diet (HFD)-induced glucose intolerance by selective breeding (designated selectively bred diet-induced glucose intolerance-prone [SDG-P] and -resistant [SDG-R], respectively). In the present study, we analyzed transgenerational changes in metabolic phenotypes in these 2 mouse colonies to explore how the distinct phenotypes have emerged through the repetitive selection. Using C57BL/6, C3H, and AKR as background strains, mice showing inferior and superior glucose tolerance after HFD feeding were selected and bred repetitively over 20 generations to produce SDG-P and SDG-R, respectively. In addition to the blood glucose levels, HFD intake and body weight were also measured over the selective breeding period. As the generations proceeded, SDG-P mice became more susceptible to HFD-induced glucose intolerance and body weight gain, whereas SDG-R mice had gradually reduced HFD intake. The differences in fasting and post-glucose challenge blood glucose levels, body weight, and HFD intake became more evident between the 2 colonies through the selective breeding, mainly due to the HFD-induced glucose metabolism impairment and body weigh...Continue Reading

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Citations

May 1, 2015·Endocrine Journal·Mototsugu NagaoShinichi Oikawa
Apr 12, 2019·Journal of Atherosclerosis and Thrombosis·Akira AsaiShinichi Oikawa
Feb 9, 2017·Marine Biotechnology·Bi Jun LiJun Hong Xia
Jan 19, 2016·Current Opinion in Lipidology·Carmen de la RochaGertrud Lund

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