Transgenerational effects of insecticides-implications for rapid pest evolution in agroecosystems

Current Opinion in Insect Science
Kristian BrevikYolanda H Chen

Abstract

Although pesticides are a major selective force in driving the evolution of insect pests, the evolutionary processes that give rise to insecticide resistance remain poorly understood. Insecticide resistance has been widely observed to increase with frequent and intense insecticide exposure, but can be lost following the relaxation of insecticide use. One possible but rarely explored explanation is that insecticide resistance may be associated with epigenetic modifications, which influence the patterning of gene expression without changing underlying DNA sequence. Epigenetic modifications such as DNA methylation, histone modifications, and small RNAs have been observed to be heritable in arthropods, but their role in the context of rapid evolution of insecticide resistance remain poorly understood. Here, we discuss evidence supporting how: firstly, insecticide-induced effects can be transgenerationally inherited; secondly, epigenetic modifications are heritable; and thirdly, epigenetic modifications are responsive to pesticide and xenobiotic stress. Therefore, pesticides may drive the evolution of resistance via epigenetic processes. Moreover, insect pests primed by pesticides may be more tolerant of other stress, further enhanc...Continue Reading

Citations

Nov 2, 2019·Ecological Applications : a Publication of the Ecological Society of America·Olivia M SmithWilliam E Snyder
May 15, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Christopher J Whelan, Jessica J Cunningham
Feb 6, 2020·Médecine sciences : M/S·Nadia AribiDominique Joly
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał KrzyżowskiJacek Francikowski

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