Transgenerational effects of maternal and grandmaternal age on offspring viability and performance in Drosophila melanogaster

Journal of Insect Physiology
Margaret C Bloch QaziChristian L Medrano

Abstract

In non-social insects, fitness is determined by relative lifetime fertility. Fertility generally declines with age as a part of senescence. For females, senescence has profound effects on fitness by decreasing viability and fertility as well as those of her offspring. However, important aspects of these maternal effects, including the cause(s) of reduced offspring performance and carry-over effects of maternal age, are poorly understood. Drosophila melanogaster is a useful system for examining potential transgenerational effects of increasing maternal age, because of their use as a model system for studying the physiology and genetic architecture of both reproduction and senescence. To test the hypothesis that female senescence has transgenerational effects on offspring viability and development, we measured the effects of maternal age on offspring survival over two generations and under two larval densities in two laboratory strains of flies (Oregon-R and Canton-S). Transgenerational effects of maternal age influence embryonic viability and embryonic to adult viability in both strains. However, the generation causing the effects, and the magnitude and direction of those effects differed by genotype. The effects of maternal age...Continue Reading

Citations

Jul 10, 2019·Genes, Brain, and Behavior·Dova B Brenman-SuttnerAnne F Simon
Aug 13, 2020·Proceedings. Biological Sciences·Edward Ivimey-Cook, Jacob Moorad
Jul 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christina M HernándezKristin E Gribble
Feb 11, 2021·Ecology Letters·Pauline VuarinGabriele Sorci
Oct 14, 2021·Proceedings. Biological Sciences·Laura M TraversAlexei A Maklakov
Dec 10, 2021·Journal of Evolutionary Biology·Susan N GershmanIan M Hamilton

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