Transgenerational effects of obesogens

Basic & Clinical Pharmacology & Toxicology
Michelle Kira Lee, Bruce Blumberg

Abstract

Obesity and associated disorders are now a global pandemic. The prevailing clinical model for obesity is overconsumption of calorie-dense food and diminished physical activity (the calories in-calories out model). However, this explanation does not account for numerous recent research findings demonstrating that a variety of environmental factors can be superimposed on diet and exercise to influence the development of obesity. The environmental obesogen model proposes that exposure to chemical obesogens during in utero and/or early life can strongly influence later predisposition to obesity. Obesogens are chemicals that inappropriately stimulate adipogenesis and fat storage, in vivo either directly or indirectly. Numerous obesogens have been identified in recent years and some of these elicit transgenerational effects on obesity as well as a variety of health end-points after exposure of pregnant F0 females. Prenatal exposure to environmental obesogens can produce lasting effects on the exposed animals and their offspring to at least the F4 generation. Recent results show that some of these transgenerational effects of obesogen exposure can be carried across the generations via alterations in chromatin structure and accessibili...Continue Reading

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Citations

Feb 19, 2020·Endocrinology·Riann Jenay Egusquiza, Bruce Blumberg
May 12, 2019·Basic & Clinical Pharmacology & Toxicology·Philippe GrandjeanPal Weihe
Apr 23, 2020·International Journal of Clinical Pharmacy·Matthew V LumBrodie M Sakakibara
Dec 9, 2020·Nature Reviews. Endocrinology·David Lopez-RodriguezAnne-Simone Parent
May 12, 2021·Expert Review of Endocrinology & Metabolism·Laura N Vandenberg
Jun 3, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M P R MachadoM F Américo
Aug 30, 2021·Environment International·Raquel Chamorro-GarcíaDaniel Zalko

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