PMID: 11604061Oct 18, 2001Paper

Transgenerational effects of preconception paternal contamination with (55)Fe

Radiation Research
K P HoyesI D Morris

Abstract

The conjecture that germline mutations induced by radiation exposure before conception may predispose subsequent offspring to cancer remains contentious. Previous experimental studies have shown that preconception paternal irradiation with (239)Pu induces perturbations in the hemopoietic systems of offspring and influences sensitivity to a secondary carcinogen. In the present study, male DBA2 mice were injected intravenously with the Auger electron emitter (55)Fe (4 kBq g(-1)) 18 or 84 days before mating with normal females. Comet analysis showed an increased incidence of DNA strand breaks in sperm from contaminated animals after 84 days, but not after 18 days, indicating spermatogonial rather than spermatid damage. Offspring were either assayed for changes in bone marrow stem cells and committed progenitors or challenged with the chemical carcinogen methyl nitrosourea (MNU, 50 mg/kg) at 10 weeks of age and monitored for the onset of malignancy. Offspring from irradiated fathers had normal peripheral blood profiles, although the stem cell population was amplified in offspring arising from those exposed to (55)Fe at 84 days before conception. Exposure to MNU significantly increased the incidence of lympho-hemopoietic malignancie...Continue Reading

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Citations

Dec 12, 2003·Fertility and Sterility·Narendra P SinghRichard E Berger
Dec 19, 2009·Environmental Health Perspectives·Donald T WigleDaniel Krewski
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ruth BarberYuri E Dubrova
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