Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

BJOG : an International Journal of Obstetrics and Gynaecology
Rebecca PainterTessa Roseboom

Abstract

Maternal undernutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. We investigated whether these effects may persist in subsequent generations. Historical cohort study. Interview during a clinic or home visit or by telephone. Men and women born in the Wilhelmina Gasthuis in Amsterdam between November 1943 and February 1947. We interviewed cohort members (F1) born around the time of the 1944-45 Dutch famine, who were exposed or unexposed to famine in utero, about their offspring (F2). Birthweight, birth length, ponderal index and health in later life (as reported by F1) of the offspring (F2) of 855 participating cohort members, according to F1 famine exposure in utero. F1 famine exposure in utero did not affect F2 (n = 1496) birthweight, but, among the offspring of famine-exposed F1 women, F2 birth length was decreased (-0.6 cm, P adjusted for F2 gender and birth order = 0.01) and F2 ponderal index was increased (+1.2 kg/m(3), P adjusted for F2 gender and birth order = 0.001). The association remained unaltered after adjusting for possible confounders. The offspring of F1 women who were exposed to famine in utero also had poor health 1.8 (95% CI 1.1-2.7) times more freque...Continue Reading

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