Transgenerational epigenetic inheritance: an open discussion

Epigenomics
Corina Nagy, Gustavo Turecki

Abstract

Much controversy surrounds the idea of transgenerational epigenetics. Recent papers argue that epigenetic marks acquired through experience are passed to offspring, but as in much of the field of epigenetics, there is lack of precision in the definitions and perhaps too much eagerness to translate animal research to humans. Here, we review operational definitions of transgenerational inheritance and the processes of epigenetic programing during early development. Subsequently, based on this background, we critically examine some recent findings of studies investigating transgenerational inheritance. Finally, we discuss possible mechanisms that may explain transgenerational inheritance, including transmission of an epigenetic blueprint, which may predispose offspring to specific epigenetic patterning. Taken together, we conclude that presently, the evidence suggesting that acquired epigenetic marks are passed to the subsequent generation remains limited.

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Citations

Jun 18, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Guy Barry
May 13, 2017·Genes·Kathryn VaillancourtGustavo Turecki
Dec 6, 2017·Journal of Molecular Endocrinology·Louise Ruby Høj IllumAnders Lade Nielsen
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May 5, 2018·International Journal of Molecular Sciences·Ariel Ernesto Cariaga-MartínezRaúl Alelú-Paz
Jan 25, 2020·Experimental & Molecular Medicine·Laurence DumeigeLaetitia Martinerie
Apr 4, 2019·Human Nature : an Interdisciplinary Biosocial Perspective·Bilinda StraightStephen Lekalgitele
Jul 17, 2016·Reproductive Toxicology·Shuk-Mei HoCarmen J Williams
Dec 4, 2021·Intensive Care Medicine Experimental·Paula Martín-VicenteLaura Amado-Rodríguez

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Methods Mentioned

BETA
chemical modifications
environmental stress

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