Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure

Environmental Pollution
Marta LombóMaría Paz Herráez

Abstract

Bisphenol A (BPA) is an endocrine disruptor used in manufacturing of plastic devices, resulting in an ubiquitous presence in the environment linked to human infertility, obesity or cardiovascular diseases. Both transcriptome and epigenome modifications lie behind these disorders that might be inherited transgenerationally when affecting germline. To assess potential effects of paternal exposure on offspring development, adult zebrafish males were exposed to BPA during spermatogenesis and mated with non-treated females. Results showed an increase in the rate of heart failures of progeny up to the F2, as well as downregulation of 5 genes involved in cardiac development in F1 embryos. Moreover, BPA causes a decrease in F0 and F1 sperm remnant mRNAs related to early development. Results reveal a paternal inheritance of changes in the insulin signaling pathway due to downregulation of insulin receptor β mRNAs, suggesting a link between BPA male exposure and disruption of cardiogenesis in forthcoming generations.

References

Oct 23, 1998·Molecular and Cellular Endocrinology·J C GouldK W Gaido
Jun 2, 2000·Chemosphere·M FürhackerH Weber
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 20, 2002·Lancet·Johannes L H Evers
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Kenji MoriyamaKazuwa Nakao
Jan 10, 2003·Nucleic Acids Research·Judy SpragueMonte Westerfield
May 14, 2004·Nature·G Charles OstermeierStephen A Krawetz
Feb 8, 2006·Biological & Pharmaceutical Bulletin·Takako IsoYasuhiro Furuichi
Jul 20, 2006·Physiological Genomics·Madhusudhan R PapasaniRodney A Hill
Jun 23, 2007·Theriogenology·A BoerkeB M Gadella
Jul 3, 2007·Developmental Biology·Ki-Hyun KimYoungsook Lee
Jul 14, 2007·Reproductive Toxicology·Yelena B WetherillScott M Belcher
Aug 4, 2007·Critical Reviews in Toxicology·Jeong-Hun KangYoshiki Katayama
Jan 12, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Calvin C WillhiteClifton J McLellan
Apr 9, 2008·Journal of Cellular Biochemistry·Claudia LalancetteStephen A Krawetz
Aug 9, 2008·Endocrinology·Yuka ToyoshimaDerek LeRoith
Apr 8, 2009·General and Comparative Endocrinology·Rüdiger W SchulzTakeshi Miura
May 22, 2010·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
Oct 19, 2010·Asian Journal of Andrology·Yasuhiro YamauchiW Steven Ward
Dec 3, 2010·Reproductive Biomedicine Online·Sandra García-HerreroMarcos Meseguer
Feb 22, 2011·Brain, Behavior, and Immunity·Marija Kundakovic, Frances A Champagne
May 3, 2011·The Journal of Veterinary Medical Science·Masato HiyamaYasuo Kiso
May 14, 2011·Zebrafish·Vanesa RoblesJuan Carlos Izpisua Belmonte
May 24, 2011·Cardiovascular Research·Jeroen Bakkers
Aug 2, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Igal A SebagLorraine E Chalifour
Feb 1, 2012·Fertility and Sterility·Toshio Hamatani
Feb 1, 2012·Journal of Assisted Reproduction and Genetics·Rima DadaAshok Agarwal
Jun 22, 2012·Environmental Science and Pollution Research International·Qiansheng HuangSijun Dong
Sep 6, 2012·International Journal of Molecular Sciences·Sher Singh, Steven Shoei-Lung Li
Feb 19, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bhavini B PatelLorraine E Chalifour
Jun 22, 2013·Biology Open·William K F TseChris K C Wong
Jul 17, 2013·Human Reproduction Update·Meritxell JodarUNKNOWN Reproductive Medicine Network
Sep 3, 2013·Reproductive Toxicology·Johanna R Rochester
Dec 7, 2013·Environmental Toxicology and Chemistry·Yu-Jie DaiDe-Sheng Pei
Jan 17, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adelheid SoubrySusan K Murphy
Mar 1, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J CorralesK L Willett
Mar 4, 2014·PloS One·Kalyan C ChapalamaduguGordon K Murdoch

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Citations

Jul 9, 2016·Environmental Epigenetics·Mark A Hanson, Michael K Skinner
Mar 26, 2016·Pharmacology & Therapeutics·Yingmei Zhang, Jun Ren
May 2, 2016·General and Comparative Endocrinology·Vanesa RoblesMarta F Riesco
Jul 1, 2016·Current Environmental Health Reports·Molly S Estill, Stephen A Krawetz
Jul 15, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sara E WirbiskyJennifer L Freeman
Sep 15, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·C LovelyJohann Eberhart
Oct 27, 2018·Journal of Developmental Origins of Health and Disease·A BansalR A Simmons
Jul 6, 2020·The Journal of Experimental Biology·Naim M BautistaWarren Burggren
Jul 2, 2020·American Journal of Epidemiology·Glen McGeeSebastien Haneuse
Oct 7, 2017·Epigenetics & Chromatin·Vincenzo Cavalieri, Giovanni Spinelli
Sep 24, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Barbara HammerSusanne Krauss-Etschmann
Oct 27, 2017·Global Challenges·Mustapha U Imam, Maznah Ismail
Aug 3, 2019·Scientific Reports·Marta F RiescoVanesa Robles
Aug 28, 2020·Frontiers in Endocrinology·Federica CariatiIda Strina
May 7, 2020·International Journal of Molecular Sciences·Olga A EfimovaAnna A Pendina
Jul 25, 2018·Environmental Epigenetics·Eric E NilssonMichael K Skinner
Oct 6, 2018·Environmental Health and Toxicology·Nivedita ChatterjeeJinhee Choi
Nov 11, 2020·International Archives of Occupational and Environmental Health·Vince Fazekas-PongorMelinda Pénzes
Nov 29, 2020·BMC Biology·Joanna RutkowskaShinichi Nakagawa
Feb 17, 2021·The Science of the Total Environment·Tiago TorresMiguel Machado Santos
Mar 5, 2021·Biological Reviews of the Cambridge Philosophical Society·Marta Lombó, Paz Herráez
Mar 7, 2021·International Journal of Molecular Sciences·Marta Lombó, María Paz Herráez
Dec 9, 2020·Environmental Pollution·Mariacristina FiliceAlfonsina Gattuso
Aug 9, 2019·Environmental Science & Technology·Shamaila FrazJoanna Y Wilson

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