Transgenerational transmission of anxiety induced by neonatal exposure to lipopolysaccharide: implications for male and female germ lines

Psychoneuroendocrinology
Adam K WalkerDeborah M Hodgson

Abstract

Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour and alters neuroendocrine responses to stress in adult rats. The current study assessed whether this anxiety-related phenotype observed in rats neonatally exposed to LPS is transferable to subsequent generations. Wistar rats were exposed to LPS (0.05 mg/kg, Salmonella enteritidis) or non-pyrogenic saline (equivolume) on postnatal days 3 and 5. In adulthood, animals were subjected to restraint and isolation stress or no stress, and subsequently evaluated for anxiety-like behaviours on the elevated plus maze, acoustic startle response, and holeboard apparatus. Blood was collected to examine corticosterone responses to stress and behavioural testing in adulthood. Animals from both treatment groups which exhibited the anxiety-like phenotype were bred with untreated partners. Maternal care of the second generation (F2) was monitored over the first week of life. In adulthood, the F2 generation underwent identical testing procedures as the parental (F1) generation. The F2 offspring of females exposed to LPS as neonates exhibited an anxiety-like phenotype in adulthood and a potentiated corticosterone response to stress (p<.05). F2 offspring of males exposed to ...Continue Reading

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Citations

Apr 10, 2013·Epigenomics·Richard G Hunter, Bruce S McEwen
Mar 1, 2012·Hormones and Behavior·Luba SominskyDeborah M Hodgson
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Sep 7, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda C KentnerMelissa D Bauman
May 6, 2021·Translational Psychiatry·Or BursteinRavid Doron

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