Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine.

Scientific Reports
Deirdre M McCarthyPradeep G Bhide

Abstract

The use of non-nutritive sweeteners such as saccharin is widely prevalent. Although saccharin is considered safe for human consumption, it produces behavioral changes in experimental animals. We report that saccharin's behavioral effects are much more pervasive than currently recognized. In a mouse model, saccharin exposure produced motor impulsivity not only in the saccharin-exposed males but also in their offspring. In addition, the offspring showed locomotor hyperactivity and working memory deficit not observed in fathers. Spermatazoal DNA was hypermethylated in the saccharin-exposed fathers, especially at dopamine receptor promoter regions, suggesting that epigenetic modification of germ cell DNA may mediate transgenerational transmission of behavioral phenotypes. Dopamine's role in hyperactivity was further highlighted by the finding that the stimulant drug methylphenidate mitigated the hyperactivity. Nicotine is another substance that is widely used. Its use via smokeless tobacco products, some of which contain saccharin, is on the rise contributing to concerns about adverse outcomes of co-exposure to saccharin and nicotine. We found that co-exposure of male mice to saccharin and nicotine produced significant behavioral i...Continue Reading

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Citations

Jun 15, 2021·Biology of Reproduction·Deirdre M McCarthy, Pradeep G Bhide
Aug 7, 2021·Brain Research Bulletin·Kartheek GaviniKodeeswaran Parameshwaran
Oct 2, 2021·Journal of Autism and Developmental Disorders·Jill EscherVictor G Corces

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Methods Mentioned

BETA
immunoprecipitation
PCR

Software Mentioned

GraphPad Prism
Methylprimer

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