Transgenic analysis of scleroderma: understanding key pathogenic events in vivo

Autoimmunity Reviews
C P Denton, D J Abraham

Abstract

Modern molecular genetic methods have allowed better understanding of established mouse models of scleroderma and also facilitated the development of new and better defined mouse strains for investigating the pathogenesis of the disease. The best characterized scleroderma animal model is the type 1 tight skin mouse (Tsk1). Backcrossing these animals with other mutant strains has been informative. These experiments implicate the IL-4 ligand-receptor axis in the development of skin fibrosis. Parallel expression analysis of genes using microarrays has provided insight into novel mediators of fibrosis including the C-C chemokine MCP-3. Other experiments suggest that embryonically defined fibroblast-specific regulatory elements may be targets for activation in this model. The same lineage-specific elements have been used to selectively activate TGF beta signaling pathways in fibrosis to generate a novel model for scleroderma and also have been used to develop systems for ligand-dependent fibroblast-specific genetic recombination that will allow further analysis key candidate genes implicated in scleroderma pathogenesis. Better mouse models will improve understanding of this intractable rheumatic disease and can be expected to ultima...Continue Reading

References

Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D MetzgerP Chambon
Mar 24, 1999·Arthritis and Rheumatism·R SgoncS A Jiménez
Apr 14, 1999·The Journal of Investigative Dermatology·T YamamotoK Nishioka
Dec 6, 2000·European Journal of Biochemistry·S ItohP Ten Dijke
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·E SaezR M Evans
Mar 27, 2001·Arthritis and Rheumatism·C P DentonB de Crombrugghe
Mar 27, 2001·Arthritis and Rheumatism·T D DodigS H Clark
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Takao KoderaConstantin A Bona
Aug 7, 2003·Trends in Genetics : TIG·Kazuhisa Nakashima, Benoit de Crombrugghe

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Citations

Jun 30, 2006·Zeitschrift für Rheumatologie·T Krieg, N Hunzelmann
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Janson C SullivanAzin Agah
Oct 19, 2011·Cell and Tissue Research·Steven Dooley, Peter ten Dijke
Oct 31, 2006·The Journal of Investigative Dermatology. Symposium Proceedings·Beate EckesThomas Krieg
Oct 26, 2012·The Journal of Investigative Dermatology·Roghieh DjafarzadehPeter J Nelson
Jul 16, 2008·Journal of Cellular and Molecular Medicine·Adam ReichDaniel J Muller
Dec 4, 2008·Fundamental & Clinical Pharmacology·Vincent RichardIsabelle Marie
Apr 25, 2016·Best Practice & Research. Clinical Rheumatology·M Marenzana, G Vande Velde
Apr 14, 2016·The Journal of Investigative Dermatology·Paola ZigrinoCornelia Mauch
Sep 20, 2005·Trends in Immunology·David J Abraham, John Varga
Sep 2, 2006·Arthritis and Rheumatism·Hidekata YasuokaCarol A Feghali-Bostwick
Sep 8, 2019·Archives of Dermatological Research·Julie K NguyenJared Jagdeo
May 5, 2005·Rheumatology·F A Wollheim

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