PMID: 9535288Apr 16, 1998Paper

Transgenic and transcriptional studies on neurosecretory cell gene expression

Cellular and Molecular Neurobiology
S J WallerDavid Murphy

Abstract

1. Studies of the regulation of neurosecretory cell gene expression suffer from the lack of suitable cell lines. Two approaches have been used to overcome this deficit: transfection of neuropeptide genes into heterologous cell lines and generation of transgenic animals. 2. Studies with heterologous cell lines have revealed the potential involvement of nuclear hormone receptors, POU proteins, and fos/jun/ATF family members in the regulation of the vasopressin and oxytocin genes. Although limited in their scope, these studies have contributed greatly to the dissection of basic properties of elements in the vasopressin and oxytocin gene promoters. 3. Transgenic mice, and more recently rats, have been used to elucidate genomic regions governing cell specificity and physiological regulation of neurosecretory gene expression. The genes encoding the neuropeptides vasopressin and oxytocin have been used in many transgenic studies, due to the well-defined expression patterns and physiology of the endogenous neuropeptides. Cell-specific and physiologically regulated expression of these transgenes has been achieved, demonstrating the action of putative repressor elements and regulation of the expression of one gene by sequences present in...Continue Reading

Citations

Dec 3, 1999·Journal of Neuroendocrinology·W S YoungE I Ginns
Mar 15, 2000·Reviews in the Neurosciences·M Bader
Jan 23, 2010·The European Journal of Neuroscience·Sabine Michaëlle DuplanJacques L Michaud
Jun 28, 2001·Physiological Reviews·J P BurbachH Gainer
Jan 23, 2021·Biomedicines·Samantha SparapaniChiara Gamberi
Sep 28, 2001·Experimental Neurology·H GainerS B House

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