Transgenic approaches to understanding the mechanisms of chemical carcinogenesis in mouse skin

Toxicology Letters
K BrownA Balmain

Abstract

The use of animal models for human cancer has proved effective in the elucidation of those molecular events which are responsible for the various stages of tumour development. Chemical carcinogenesis in mouse skin has been studied as a model for human squamous cancer for several decades, and analysis of this model has led to the identification of a number of the changes which are involved in the evolution of malignancy. The use of transgenic and knockout mice offers a further avenue of advancement, allowing refinement of the model, and the ability to examine the consequences of individual events in vivo in greater detail. Additionally, crossing different transgenic or knockout animals represents a powerful tool to study the cumulative effects of several genetic alterations acting in concert.

References

Jul 5, 1991·Science·M HollsteinC C Harris
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K BrownA Balmain
Jul 1, 1990·Trends in Genetics : TIG·B A Ponder
Dec 8, 1989·Science·D Hanahan
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Mar 9, 1984·Science·A L Murphree, W F Benedict
Jun 1, 1995·Current Biology : CB·E P BrandonG S McKnight
Aug 1, 1995·Current Biology : CB·E P BrandonG S McKnight
Mar 1, 1995·Molecular Carcinogenesis·C J Kemp

❮ Previous
Next ❯

Citations

Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Gerhard FürstenbergerPeter Krieg
Mar 4, 2000·Environmental Health Perspectives·J McCannC N Rafferty
Nov 14, 1997·Regulatory Toxicology and Pharmacology : RTP·T J FlammangP P Fu
May 1, 2001·Current Protocols in Toxicology·W C Ladiges, C B Ware
Sep 24, 2008·Journal of Clinical Nursing·Kerry Reid-SearlBrenda Happell
Jul 21, 2009·International Journal of Occupational Medicine and Environmental Health·Małgorzata EwertowskaMirosława Szaufer-Hajdrych

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.