Transgenic B lymphocytes expressing a human cold agglutinin escape tolerance following experimental infection of mice by Mycoplasma pulmonis

European Journal of Immunology
S HavouisC Pourcel

Abstract

Several microbial infections, including Mycoplasma pneumoniae respiratory infection, are capable, in man, of transiently inducing the expression of anti-red blood cell autoantibody called cold agglutinins (CA). To analyze the mechanisms by which immune tolerance is broken following a mycoplasma infection, we used transgenic mice expressing a pathogenic human CA, designated CA-GAS, specific for sialylated carbohydrates. In these mice peripheral deletion of autoreactive B lymphocytes and receptor editing, prevent the development of autoimmune hemolytic anemia. Experimental infections of transgenic mice with Mycoplasma pulmonis resulted in a high anti-mycoplasma antibody response (despite a severe B cell depletion at the onset of infection), and an important induction of serum CA concentrations, reaching in some mice pathological titers. Whereas in naïve mice, only a small percentage of CA-expressing cells could be detected, in infected mice, a majority of circulating B lymphocytes were large B220(-) cells, which expressed the transgenic immunoglobulin. Immunization of the transgenic mice with keyhole limpet hemocyanin and Freund's adjuvant, to nonspecifically stimulate the expression of the passenger transgenes, only moderately i...Continue Reading

References

Oct 1, 1978·Infection and Immunity·F A JanneyC Howe
Oct 1, 1978·Infection and Immunity·S A Horowitz, G H Cassell
Aug 8, 1991·Nature·C C GoodnowE Adams
Nov 28, 1991·Nature·D M RussellD Nemazee
Dec 1, 1989·Immunological Reviews·E Ruuth, F Praz
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M ErisP D Hodgkin
Nov 26, 1993·Science·M F BachmannR M Zinkernagel
Mar 1, 1993·Journal of Clinical Microbiology·F J van KuppeveldJ T van der Logt
May 3, 1996·Cell·B L Kotzin
Dec 1, 1995·Current Opinion in Immunology·A CoutinhoS Avrameas
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·T Feizi, R W Loveless
Dec 1, 1996·Infection and Immunity·S C CartnerJ R Lindsey
May 19, 1997·The Journal of Experimental Medicine·T FehrR M Zinkernagel
Oct 23, 1997·British Journal of Haematology·G DumasG Dighiero
Apr 7, 1998·Immunity·M K SlifkaR Ahmed
Jul 7, 1998·The Journal of Experimental Medicine·T LitzenburgerA Iglesias
Jul 31, 1998·Nature·C Benoist, D Mathis
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S RazinY Naot
Jul 3, 1999·Science·K HayakawaR R Hardy
Aug 18, 1999·Immunological Reviews·M S Horwitz, N Sarvetnick
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I R RifkinA Marshak-Rothstein
Jun 20, 2001·The Journal of Experimental Medicine·M F Bachmann, M Kopf
May 1, 1992·Journal of the American Society for Mass Spectrometry·G ThielkingH F Grützmacher

❮ Previous
Next ❯

Citations

Aug 30, 2005·Annals of the New York Academy of Sciences·Caterina Toriani-Terenzi, Enzo Fagiolo
Jan 24, 2006·Clinical and Vaccine Immunology : CVI·L E HoelzleM M Wittenbrink
Aug 19, 2007·Journal of Leukocyte Biology·Ben J C Quah, Helen C O'Neill
Jun 15, 2007·British Journal of Haematology·Morie A Gertz
Dec 20, 2011·Autoimmunity Reviews·Carolina Duarte-ReyM Eric Gershwin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
J W SimeckaJ K Davis
Zentralblatt Für Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie
G Biberfeld
© 2022 Meta ULC. All rights reserved