PMID: 22567930May 10, 2012Paper

Transgenic cell cultures that synthesize neurotrophic factors and the possibility of therapeutic use of its cells

Ontogenez
G V PavlovaA V Revishchin

Abstract

Under the leadership of Corresponding Member of the Russian Academy of Sciences L.I. Korochkin, the Laboratory of Neurogenetics and Developmental Genetics (Institute of Gene Biology, Russian Academy of Sciences) for many years has been conducting studies of nervous system development, neural cell differentiation, and application of gene and cell technology to cure neurodegenerative diseases. The results of the study initiated by L.I. Korochkin and continued by his scientific successors support the direction of allocation of transgenic neurotrofic factors and heat-shock proteins as neuroprotectors for cell therapy. Potential for usage of promoter of HSP70 heat-shock gene of Drosophila to create transgenic constructs for therapy has been shown. Further improvement of technology of nonvirus transfer for therapeutic genes, as well as production of multicomponent genetic constructs coding several therapeutic factors with synergy effect, would stimulate creation of efficient cell medicals to cure neurodegenerative diseases.

References

Oct 1, 1996·Experimental Neurology·M L PriceA C Granholm
Jan 8, 1999·Cell Stress & Chaperones·A Samali, S Orrenius
Apr 12, 2002·Brain Research. Developmental Brain Research·R A PoltavtsevaG T Sukhikh
Jul 10, 2003·Lancet Neurology·Anders BjörklundRoger Barker

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Vestnik Rossiĭskoĭ akademii meditsinskikh nauk
I A Ivanova-SmolenskaiaI V Ovchinnikov
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Jeffrey L Bennett
Current Neurology and Neuroscience Reports
Massimo Zeviani, Antonella Spinazzola
© 2021 Meta ULC. All rights reserved