Abstract
Matrix metalloproteinase-9 (MMP-9) has been proposed to be an important modulator of atherosclerotic plaque vulnerability. We generated a transgenic (tg) model expressing human proMMP-9 in macrophages, using the scavenger receptor enhancer/promoter A. This model was crossed into the double Apoe/Timp-1 knockout background. After 16 weeks of a high-fat diet, there were no significant changes in plaque size in the proximal aortas between the four groups of the study population (Apoe(-/-), Apoe(-/-)/MMP-9tg, Apoe(-/-)/Timp-1(-/-), and Apoe(-/-)/MMP-9tg/Timp-1(-/-)), and, in the Timp-1 knockout background, MMP-9 transgenic mice and control littermates had similar micro-aneurysm formation. However, lesions in Apoe(-/-)/MMP-9tg/Timp-1(-/-) mice contained significantly more collagen compared to the three other groups (P<0.005). Culture supernatants from elicited Apoe(-/-)/MMP-9tg/Timp-1(-/-) macrophages contained higher levels of active TGF-beta than the three other groups (P<0.05), suggesting that augmented collagen deposition resulted from an increase in TGF-beta activation due to transgenic MMP-9 in the Timp-1(-/-) background. This study indicates that, in human atherosclerosis, increased MMP-9 activity could up-regulate collagen de...Continue Reading
References
Jul 1, 1995·The Journal of Clinical Investigation·R W ThompsonW C Parks
Aug 4, 1995·The Journal of Biological Chemistry·Y OgataH Nagase
Apr 15, 1995·Circulation·D L BrownJ M Isner
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·A HorvaiC K Glass
Dec 1, 1994·The Journal of Clinical Investigation·Z S GalisP Libby
Apr 13, 1999·Circulation·B ZhangA M Henney
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·D F GibbsJ Varani
Jul 23, 1999·Annals of the New York Academy of Sciences·A Y JengM F Prescott
Jun 7, 2000·The Journal of Clinical Investigation·R PyoR W Thompson
Feb 22, 2001·Circulation·Y FukumotoM Aikawa
Nov 2, 2002·Circulation Research·Aesim Cho, Michael A Reidy
Nov 2, 2002·Circulation Research·Zorina S GalisEugen Ivan
Dec 20, 2002·Nature·Peter Libby
Feb 5, 2003·Cardiovascular Research·Kunio MorishigeAkira Takeshita
Mar 3, 2004·Circulation·Aernout LuttunLieve Moons
Dec 25, 2004·Physiological Reviews·Andrew C Newby
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason L JohnsonChristopher L Jackson
Citations
Jan 29, 2011·Current Atherosclerosis Reports·Daniel F J Ketelhuth, Magnus Bäck
Nov 8, 2011·Assay and Drug Development Technologies·Helene Skjøt-ArkilMorten A Karsdal
Feb 21, 2013·Cardiology in Review·Dimitry A ChistiakovAlexander N Orekhov
Nov 11, 2010·Journal of Hypertension·Joseph George, Jeanine D'Armiento
Jul 3, 2010·Pathology International·Takayuki ShiomiYasunori Okada
Nov 27, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Divya MehraJeanine D'Armiento
Jul 29, 2010·Journal of Inflammation·Gnanapragasam ArunachalamIrfan Rahman
Mar 29, 2014·PLoS Neglected Tropical Diseases·Kirsten GeneugelijkWendy W J van de Sande
Aug 27, 2014·International Immunopharmacology·Su-Jie JiaMing Zhao
Dec 2, 2015·Experimental and Therapeutic Medicine·Mingxue ZhouHongxu Liu
Nov 22, 2011·Molecular Aspects of Medicine·Diego SbardellaMassimo Coletta
Feb 1, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Andrew C Newby
Jan 10, 2014·Atherosclerosis·Yonggang MaMerry L Lindsey
Jul 8, 2016·SpringerPlus·Di CuiFuhua Yan
Mar 4, 2017·PloS One·Stephanie E SeidlBarbara M Schreiber
Mar 4, 2020·Journal of Cellular and Molecular Medicine·Yajie ChenJianglin Fan
Oct 22, 2020·Mediators of Inflammation·Tiewei LiJunmei Yang