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Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice

Biochemical and Biophysical Research Communications

Apr 12, 2002

Ko-ichi MorimotoT Shirasawa

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Abstract

Hereditary multiple exostoses (HME), a dominantly inherited disorder characterized by multiple cartilaginous tumors, is caused by mutations in the gene for, EXT1 or EXT2. Recent studies have revealed that EXT1 and EXT2 are required for the biosynthesis of heparan sulfate and exert maxim...read more

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Bone Development
Exertion
Exostoses
Hereditary Multiple Exostoses
N-Acetylglucosaminyltransferases
Neoplasms
Regulation of Chondrocyte Differentiation
X-Ray Computed Tomography
Chondrocyte
House mice
Paper Details
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Proceedings of the National Academy of Sciences of the United States of America

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

Proceedings of the National Academy of Sciences of the United States of AmericaJanuary 19, 2000
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Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice

Biochemical and Biophysical Research Communications

Apr 12, 2002

Ko-ichi MorimotoT Shirasawa

PMID: 11944914

DOI: 10.1006/bbrc.2002.6770

Abstract

Hereditary multiple exostoses (HME), a dominantly inherited disorder characterized by multiple cartilaginous tumors, is caused by mutations in the gene for, EXT1 or EXT2. Recent studies have revealed that EXT1 and EXT2 are required for the biosynthesis of heparan sulfate and exert maxim...read more

Mentioned in this Paper

Bone Development
Exertion
Exostoses
Hereditary Multiple Exostoses
N-Acetylglucosaminyltransferases
Neoplasms
Regulation of Chondrocyte Differentiation
X-Ray Computed Tomography
Chondrocyte
House mice

Feeds With Similar Papers

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Osteochondroma

Osteochondromas involve an overgrowth of catilage and bone. Here is the latest research on osteochondromas.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

Proceedings of the National Academy of Sciences of the United States of AmericaJanuary 19, 2000
C McCormickF Tufaro
Paper Details
References
  • References
  • Citations10
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations10
1

Download from

Publisher
PubMed
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