PMID: 9444969Jan 28, 1998Paper

Transgenic hypertensive rats show a reduced angiotensin II induced [Ca2+]i response in glomerular mesangial cells

Life Sciences
M TepelW Zidek

Abstract

The effects of angiotensin II (Ang II) induced changes of cytosolic free calcium concentration ([Ca2+]i) and growth response were investigated in transgenic TGR(mREN2)27 rats, a strain showing fulminant hypertension after the mouse Ren-2d renin gene has been integrated into its genome, in age-matched normotensive Sprague-Dawley rats (SD), in spontaneously hypertensive rats of the Münster strain (SHR), and in normotensive Wistar-Kyoto rats (WKY). In each strain the Ang II induced changes of [Ca2+]i were measured in cultured glomerular mesangial cells (MC) using the calcium-sensitive fluorescent dye, fura2. Resting [Ca2+]i was not significantly different between the strains tested. The Ang II induced [Ca2+]i rise was significantly less in MC from TGR(mREN2)27 compared to SD (peak level at 200 seconds: 161 +/- 15 nmol/L vs 217 +/- 43 nmol/L; mean +/- SEM; p<0.05). In the absence of external calcium, the Ang II induced [Ca2+]i increase was similar in MC from TGR(mREN2)27 and SD, indicating that the Ang II induced trans-plasma membrane calcium influx but not the calcium release is impaired in TGR(mREN2)27. The arginine vasopressin or endothelin induced [Ca2+]i increase were not significantly different in MC from TGR(mREN2)27 and SD....Continue Reading

References

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