PMID: 2109035Apr 1, 1990Paper

Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity

The Journal of Experimental Medicine
M BonnevilleS Tonegawa

Abstract

gamma/delta T cells with different TCR repertoires are compartmentalized in different epithelia. This raises the possibility that the TCR-gamma/delta directs homing of T cells to these epithelia. Alternatively, the signals that induce TCR-gamma/delta expression in developing T cells may also induce homing properties in such cells, presumably in the form of cell surface receptors. We have examined this issue by studying the homing of gamma/delta T cells in transgenic mice constructed with specific pairs of rearranged gamma and delta genes. In such mice, most gamma/delta T cells express the transgene-encoded TCR. We find that homing to both skin and gut epithelia is a property of T cells and is not determined by the type of gamma and delta genes used to encode their TCR. We also studied the effect of TCR replacement on the expression of Thy-1 and CD8 proteins on the gamma/delta T cells associated with gut epithelia. Our results show that the expression of the appropriate type of TCR-gamma/delta is not required for the Thy-1 expression by these T cells, suggesting that Thy-1 is not an activation marker. In contrast, CD8 expression by gut gamma/delta T cells seems to depend on the expression of the appropriate type of TCR.

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Citations

Jan 1, 1992·Immunologic Research·L Lefrançois
Jan 1, 1991·Immunologic Research·T A BarrettJ A Bluestone
Sep 1, 1990·Research in Immunology·S Kyes, A Hayday
Sep 1, 1990·Research in Immunology·C A Janeway
Apr 1, 1992·Current Opinion in Immunology·W Haas, S Tonegawa
Feb 1, 1994·Current Opinion in Immunology·M Kronenberg
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Jan 24, 2007·Nature Immunology·Adrian C Hayday, Daniel J Pennington
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R HershbergM Kronenberg
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A BandeiraS Tonegawa
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SpanerR A Phillips
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·H KomanoS Itohara
Jul 1, 1991·The Journal of Experimental Medicine·M WuS Tonegawa
Jan 1, 1992·The Journal of Experimental Medicine·T A BarrettJ A Bluestone
Nov 21, 2001·The Journal of Experimental Medicine·I FerreroH R MacDonald
Apr 3, 2002·The Journal of Experimental Medicine·Michael GirardiRobert E Tigelaar
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Oct 28, 2014·Frontiers in Immunology·David Vermijlen, Immo Prinz
Dec 16, 2017·Current Pharmacology Reports·Madeleine D Hu, Karen L Edelblum
Apr 1, 1996·European Journal of Immunology·A BirkhoferH Fricke

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