PMID: 8613482Nov 1, 1995Paper

Transgenic mice that express different forms of the influenza virus hemagglutinin as a neo-self-antigen

Journal of Clinical Immunology
Andrew J CatonD M Cerasoli

Abstract

We have generated transgenic mouse lineages that express the influenza virus hemagglutinin in different physical forms. One kind expresses the full-length hemagglutinin molecule as a cell surface glycoprotein and can be recognized by hemagglutinin-specific B and T cells. The other expresses a truncated polypeptide corresponding to the N-terminal third of the hemagglutinin molecule. This polypeptide encodes known hemagglutinin-specific T-cell determinants; however, it contains no native B-cell epitopes, since these depend on the conformation of the fully folded protein. In each case, the hemagglutinin transgenic mice display ubiquitous expression of transgenic messenger RNA and induce T-cell tolerance to the transgene-encoded T-cell determinant site 1. Thus, the hemagglutinin is a neo-self-antigen in both kinds of hemagglutinin transgenic mice and should provide a useful system for understanding the factors and mechanisms that govern tolerance and autoimmunity to self-antigens.

References

Jan 1, 1990·Annual Review of Immunology·H von Boehmer
Nov 1, 1989·Somatic Cell and Molecular Genetics·A M ChanC S Cooper
Sep 1, 1966·The Journal of Experimental Medicine· Fazekas de St Groth, R G Webster
Jan 28, 1994·Cell·G J Nossal

❮ Previous
Next ❯

Citations

Feb 28, 1998·Immunologic Research·A J CatonF F Shih
Dec 20, 2000·The Journal of Experimental Medicine·A J ReedA J Caton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.