PMID: 8613884Apr 1, 1996Paper

Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency

The Journal of Nutrition
T DaltonG K Andrews

Abstract

Transgenic mice that overexpress metallothionein-I (MT-I) accumulate mo re MT-I and zinc in major organs than do control mice. The effects of overexpression of MT-I on resistance to dietary zinc deficiency were examined by feeding transgenic and control mice a zinc-deficient (0.5-1.5 micron/gram) or a zinc adequate (50 micron/g) diet and by measuring effects on pregnancy. When pregnant mice were maintained under conditions of dietary zinc deficiency, the number of resorptions and teratogenic defects of fetuses was greatly reduced in transgenic compared with control mice. Differences between transgenic and controls were not apparent at d 8 of pregnancy (d 1 = vaginal plug) but were apparent by d 14. This result suggests that the larger maternal zinc pool in the transgenic females allows fetal development to progress normally for a longer period of time. However, neither transgenic nor control zinc-deficient mice could complete pregnancy. Pancreatic MT concentrations were the greatest in zinc adequate transgenic mice. Moreover, there was >10-fold more MT per gram wet weight in the pancreas of transgenic mice than in any other organ examined. Pancreatic MT concentrations were an exceptionally sensitive indicator of zinc deficiency...Continue Reading

Citations

May 10, 2000·The Journal of Nutrition·S R Davis, R J Cousins
Jun 21, 2005·Molecular and Cellular Biology·Jodi Dufner-BeattieGlen K Andrews
May 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·Ming-Yu JouBo Lönnerdal
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Yasmina MansoJuan Hidalgo
Mar 20, 2019·International Journal of Molecular Sciences·Rhiannon V McNeillJennifer Southgate
Jun 13, 2003·The Journal of Biological Chemistry·Jodi Dufner-BeattieGlen K Andrews
May 23, 2001·Experimental Biology and Medicine·S F Simon, C G Taylor
Oct 5, 2006·Experimental Biology and Medicine·Wei-Qiang ChenYan Hong
Apr 9, 2008·Genesis : the Journal of Genetics and Development·Taiho KambeGlen K Andrews
Dec 1, 2009·Biological Trace Element Research·Giulia AndreaniGloria Isani
May 15, 2015·The Journal of Toxicological Sciences·Tomoki KimuraNorio Itoh
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M van Lookeren CampagneD G Lowe
Apr 8, 2000·Critical Reviews in Biochemistry and Molecular Biology·A T MilesV Rodilla
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D Palmiter
Sep 29, 2004·Genesis : the Journal of Genetics and Development·Glen K AndrewsRichard D Palmiter
May 20, 1999·Annual Review of Pharmacology and Toxicology·T P DaltonA Puga
Sep 17, 2005·American Journal of Respiratory Cell and Molecular Biology·Scott C WesselkamperGeorge D Leikauf
May 3, 2006·Genesis : the Journal of Genetics and Development·Jodi Dufner-BeattieGlen K Andrews
May 20, 1999·Annual Review of Pharmacology and Toxicology·C D KlaassenS Choudhuri
Oct 4, 2003·The Journal of Biological Chemistry·Jodi Dufner-BeattieGlen K Andrews
Dec 26, 2001·The Journal of Experimental Medicine·W WaelputC Libert
May 14, 2009·Mediators of Inflammation·Ken-ichiro InoueMasahiko Satoh
Nov 25, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Benjamin P Weaver, Glen K Andrews
Jul 22, 2015·PloS One·Wen-Jie ZhaoHong-Zhen Lian
Aug 23, 2000·The Journal of Biological Chemistry·S J LangmadeG K Andrews

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